Increased sympathetic modulation and decreased response of the heart rate variability in controlled asthma

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Adriana Sanches Garcia-AraújoAudrey Borghi-Silva


To compare the autonomic modulation of heart rate (HR) in asthmatic and healthy volunteers to correlate it with the forced expiratory volume in the first second (FEV1). Ten healthy and 14 asthmatic volunteers were included in this cross-sectional study. The volunteers underwent a cardiopulmonary exercise test, spirometry and a register of both resting heart rate variability (HRV) in the supine and seated positions along with HRV during the respiratory sinus arrhythmia maneuver (M-RSA). At rest in supine, asthmatic volunteers presented a higher HR (77.1 ± 9.9 vs. 68.7 ± 8.7 bpm), shorter interval between two R waves (R-Ri) (807.5 ± 107.2 vs. 887.5 ± 112.7 ms) when compared with the healthy volunteers, respectively. Moreover, in the frequency domain of HRV, there was increased low frequency (LF) index (50.4 ± 17.1 vs. 29.2 ± 11.1 n.u.) and decreased high frequency (HF) index (49.4 ± 17.1 vs. 70.7 ± 11.1 n.u.). During the M-RSA, the asthmatic presented higher HR (82.6 ± 10.0 vs. 72.4 ± 7.6 bpm) and lower values of R-Ri (746.4 ± 92.1 vs. 846.4 ± 81.4 ms) and approximate entropy (ApEn) (0.7 ± 0.0 vs. 0.8 ± 0.1). FEV1 was strongly correlated with the change of the continuous beat-to-beat variability of HR (SD2) index from the seated ...Continue Reading


Nov 1, 1975·Journal of Applied Physiology·P G Katona, F Jih
Apr 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·C S GarrardD Gordon
May 1, 1993·Chest·M S Skorodin
Jan 1, 1997·Journal of Hypertension·P Palatini, S Julius
Apr 13, 2001·Journal of the American College of Cardiology·T H MäkikallioR J Myerburg
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S M Pincus
Aug 6, 2002·The American Journal of Cardiology·Jari M TapanainenH Huikuri
Jan 31, 2004·American Journal of Physiology. Heart and Circulatory Physiology·P GrossmanM Spoerle
Aug 9, 2005·European Journal of Applied Physiology·S Carrasco-SosaOscar Yáñez-Suárez
May 27, 2006·Journal of Applied Physiology·Brendan J Canning
Nov 17, 2009·International Journal of Cardiology·Julian F ThayerJos F Brosschot
Jun 29, 2010·Medicine and Science in Sports and Exercise·Felipe Augusto Rodrigues MendesCelso Ricardo Fernandes Carvalho
Nov 6, 2010·Journal of Clinical Nursing·Yueh-Shia TsaiChii Jeng
Apr 12, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Evelim L F Dantas GomesDirceu Costa
Sep 24, 2013·Computer Methods and Programs in Biomedicine·Mika P TarvainenPasi A Karjalainen

Related Concepts

Autonomic Nervous System
Prevalence Studies
Forced Expiratory Volume Function
Pulse Rate
Airway Obstruction
Cross-Sectional Studies
Heart Rate

Related Feeds


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Related Papers

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Bülent E SekerelKudret Aytemir
© 2021 Meta ULC. All rights reserved