PMID: 75239Feb 1, 1978Paper

Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: a possible mechanism for H-2 linked control of virus-induced neoplasia

The Journal of Experimental Medicine
D MerueloH O McDevitt

Abstract

Previous studies from this laboratory have mapped resistance and/or susceptibility to radiation-induced leukemia virus (RadLV)-induced neoplasia to the H-2D region. H-2 linked effects on virus replication can be detected subsequent to the initial virus infection, and clear-cut differences in numbers of virus infected thymus cells can be detected as early as 5 wk after RadLV inoculation. Rapid increases in cellular synthesis and cell surface expression of H-2 antigens are detectable immediately after virus inoculation. These changes have been studied by immunofluorescence, absorption, cell surface iodination followed by sodium dodecyl-sulfate-polyacrylamide gel electrophoresis, and two dimensional gel electrophoretic analysis of internally labeled lymphocyte proteins. Expression of H-2K molecules is significantly increased in cells of susceptible and resistant animals. However, significant increases in expression of H-2D antigens occurs only on thymus cells from resistant strains (H-2Dd). Transformed cells of resistant and susceptible H-2 haplotypes adapted to tissue culture lack detectable H-2 antigens as determined by serological absorption studies. It is argued that altered expression of H-2 antigens plays a very significant ...Continue Reading

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Citations

Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I HeronK Berg
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D MerueloH O McDevitt
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S Ostrand-Rosenberg, A Cohn
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D MerueloA Pellicer
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D MerueloA Rossomando
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D MerueloA Pellicer
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D MerueloA L Mellor
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G A ColeS Ostrand-Rosenberg
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D MerueloD Lavie
Jan 1, 1979·Journal of Toxicology and Environmental Health·S J O'Brien, M C Rice
May 1, 1986·The Journal of Experimental Medicine·M ZijlstraC J Melief
Aug 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·G D BrownD Meruelo
Jan 1, 1990·Cancer Investigation·F C AustinJ A Sogn
Aug 1, 1979·International Journal of Cancer. Journal International Du Cancer·M LiebermanH S Kaplan
Apr 1, 1990·Journal of Autoimmunity·A M Krieg, A D Steinberg
Aug 1, 1989·Journal of Immunogenetics·G D Brown, D Meruelo
Jan 1, 1979·Annals of the New York Academy of Sciences·G Sonnenfeld, T C Merigan
Feb 1, 1980·Journal of Immunogenetics·D Meruelo
Jun 20, 1997·The Journal of Biological Chemistry·N IshiguroD Meruelo
Jul 29, 1992·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J F Miller

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