Increased systemic immune activation and inflammatory profile of long-term HIV-infected ART-controlled patients is related to personal factors, but not to markers of HIV infection severity

The Journal of Antimicrobial Chemotherapy
Jean-Philippe BastardANRS CO8 APROCO-COPILOTE Cohort Study Group

Abstract

The objective of this study was to analyse the respective roles of personal factors and HIV infection markers on the systemic immune activation/inflammatory profile of long-term antiretroviral treatment-controlled patients. A panel of soluble immune activation/inflammatory biomarkers was measured in 352 HIV-infected treatment-controlled patients from the APROCO-COPILOTE cohort, all of whom were started on a PI in 1997-99 and had a final evaluation 11 years later, and in 59 healthy controls. A total of 81.5% of the patients were male, with the following characteristics: median age 49 years; 620 CD4 cells/mm(3); 756 CD8 cells/mm(3); CD4/CD8 ratio 0.81; BMI 23.0 kg/m(2); waist-to-hip ratio 0.95. Markers of inflammation-high-sensitivity (hs) IL-6 (median and IQR) (1.3 pg/L, 0.7-2.6), hs C-reactive protein (CRP) (2.1 mg/L, 0.9-4.5) and D-dimer (252 ng/mL, 177-374)-were elevated compared with healthy controls (P < 0.001) and strongly related to each other, as were markers of immune activation [soluble (s) CD14 (1356 ng/mL, 1027-1818), β2-microglobulin (2.4 mg/L, 2.0-3.1) and cystatin-C (0.93 mg/L, 0.82-1.1)]. Inflammatory and immune activation markers were also associated with each other. In HIV-infected patients: age was related to ...Continue Reading

References

Jul 27, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·V Le MoingUNKNOWN APROCO Study Group
Aug 16, 2006·Annals of Internal Medicine·Michael G ShlipakDavid S Siscovick
Nov 14, 2007·Archives of Internal Medicine·Michelle C OddenMichael G Shlipak
Apr 2, 2008·Obesity·Christina C WeeMurray A Mittleman
Oct 24, 2008·PLoS Medicine·Lewis H KullerUNKNOWN INSIGHT SMART Study Group
Dec 4, 2008·AIDS·Amanda MocroftUNKNOWN INSIGHT SMART Study Group
Jul 16, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Tadeusz Wojciech LapinskiRobert Flisiak
Mar 23, 2010·Aging Clinical and Experimental Research·Freddy Tita-NwaLuigi Ferrucci
May 8, 2010·The Journal of Infectious Diseases·Jacqueline NeuhausJames D Neaton
Jan 22, 2011·The Journal of Infectious Diseases·Netanya G SandlerUNKNOWN INSIGHT SMART Study Group
Apr 13, 2011·AIDS Research and Human Retroviruses·Edgar Turner OvertonUNKNOWN Sun Study Investigators
Apr 27, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kaku A ArmahMatthew Freiberg
May 23, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sylvie LangUNKNOWN French Hospital Database on HIV (FHDH)–ANRS CO4
Sep 13, 2012·PloS One·Daniel A DuprezUNKNOWN INSIGHT SMART Study Group
Jan 24, 2013·The Journal of Clinical Hypertension·Ingjerd W MannerIngrid Os
Nov 28, 2013·Current Opinion in HIV and AIDS·Amit C AchhraMatthew G Law
Dec 5, 2013·AIDS·Elizabeth HamlynUNKNOWN SPARTAC Trial Investigators
Jan 15, 2014·Current HIV/AIDS Reports·Anna C HearpsSuzanne M Crowe
Mar 15, 2014·PloS One·Alvaro H BorgesUNKNOWN SILCAAT Scientific Committee
Apr 2, 2014·Annals of Internal Medicine·Wendy S PostLisa P Jacobson
May 16, 2014·Current Opinion in HIV and AIDS·Corinne VigourouxJacqueline Capeau
May 16, 2014·Current Opinion in HIV and AIDS·Dominique Costagliola
May 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Claudio Franceschi, Judith Campisi
May 30, 2014·Journal of the American Heart Association·Anna D NordellUNKNOWN SILCAAT Scientific Committee
Sep 4, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judith SchoutenUNKNOWN AGEhIV Cohort Study Group

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Citations

Jun 8, 2018·Neurology·Hannah OppenheimUNKNOWN HIV Neurobehavioral Research Program (HNRP)
Aug 5, 2019·Annals of the Rheumatic Diseases·Samuel DeshayesUNKNOWN AA amyloidosis Study Group
Sep 16, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liz SimonPatricia E Molina

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