Increased T-helper interferon-gamma-secreting cells in obese children

European Journal of Endocrinology
Lucia PacificoClaudio Chiesa

Abstract

Leptin, an adipocyte-secreted hormone, has emerged as a potential candidate for the link between obesity and the proinflammatory state. Specifically, leptin modulates T-helper (Th) cells toward a Th1 phenotype, with the secretion of proinflammatory cytokines. The aim of this study was to evaluate the Th1/Th2 balance in obese children and its relation with hormonal and metabolic features. In 50 obese children and 20 control children, we measured the CD4-positive Th cells that secrete interferon (IFN)-gamma or interleukin (IL)-2 (taken as an index of Th1 cells), and IL-4 (taken as an index of Th2 cells) as well as serum glucose, insulin, insulin resistance (IR) index (as homeostasis model assessment model (HOMA)), lipid profile, aminotransferases, leptin and ghrelin. Obese children also underwent dual energy X-ray absorptiometry scan measurements, and liver ultrasound scanning. Geometric mean percentages of IL-2- and IL-4-CD4 secreting cells in obese children were not significantly different from those found in control children. However, the geometric mean percentage of CD4-positive T cells secreting IFN-gamma was significantly higher in the obese than in the control (P < 0.0001, t-test) group. Within the entire group of study ch...Continue Reading

Citations

Jan 19, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Flora IppolitiRita Businaro
Jun 12, 2013·Trends in Molecular Medicine·Gökhan CildirVinay Tergaonkar
Nov 5, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M Sumarac-DumanovicD Micic
Sep 13, 2013·Journal of the American College of Nutrition·Mahdieh Abbasalizad FarhangiAli-Akbar Saboor-Yaraghi
Mar 2, 2011·Diabetes Technology & Therapeutics·Jayagopi SurendarVivekanandhan Aravindhan
Jan 24, 2008·Infection and Immunity·Edward R KabyemelaPatrick E Duffy
Oct 31, 2009·Journal of Applied Physiology·Stephanie A Shore
Jun 16, 2012·Current Gerontology and Geriatrics Research·Rita BusinaroAndrea Fuso
Mar 22, 2008·Pediatric Research·Lucia PacificoClaudio Chiesa
Oct 3, 2013·International Journal of Molecular Sciences·Luisa VonghiaSven Francque
Mar 29, 2014·Cholesterol·Joshua S WootenRon C Hoogeveen
Jan 5, 2014·Cardiovascular Diabetology·Haridoss MadhumithaVivekanandhan Aravindhan
Nov 22, 2013·Seminars in Immunopathology·Sonia M Najjar, Lucia Russo
Jul 10, 2014·The Journal of Endocrinology·Milos Mraz, Martin Haluzik
Sep 29, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Anne E DixonRubin I Cohen
Jan 22, 2013·Seminars in Immunology·Chengyi Jenny ShuDiane Mathis
Jul 7, 2015·Mediators of Inflammation·Melissa Hui Yen ChngEdgar G Engleman
Jan 13, 2015·Trends in Endocrinology and Metabolism : TEM·Blanche C IpBarbara S Nikolajczyk
Sep 10, 2016·Journal of Diabetes Research·Vivekanandhan Aravindhan, Haridoss Madhumitha
Nov 15, 2016·Nature Communications·Renee L GreerNatalia Shulzhenko
Oct 23, 2016·Journal of Proteome Research·Carly B GarrisonPaul D Lampe
Oct 22, 2009·Natural Product Research·Tatiana Fernanda BachiegaJosé Maurício Sforcin
Mar 14, 2017·Cellular Immunology·Ambreen Asghar, Nadeem Sheikh
Feb 26, 2016·Archives of Endocrinology and Metabolism·Mahdieh Abbasalizad FarhangiSeyyed Ali Keshavarz
Oct 8, 2011·Chest·Deepa RastogiRaanan Arens
Apr 12, 2012·Diabetes/metabolism Research and Reviews·A ViardotK Samaras
Jul 6, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Kelsey L McAlisterDaniela A Rubin
Oct 20, 2018·Current Diabetes Reports·Thomas Reinehr, Christian Ludwig Roth
Jul 17, 2010·Annals of the New York Academy of Sciences·Gregory F Oxenkrug
Jul 17, 2010·Annals of the New York Academy of Sciences·Gregory F Oxenkrug, Paul Summergrad
Oct 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lucia PacificoClaudio Chiesa
Oct 21, 2006·Journal of Applied Physiology·Stephanie A Shore
Jan 30, 2009·American Journal of Physiology. Endocrinology and Metabolism·Sonia Do CarmoEric Rassart
Apr 9, 2010·The Journal of Clinical Endocrinology and Metabolism·A ViardotK Samaras
Feb 18, 2012·Influenza and Other Respiratory Viruses·Erik A KarlssonStacey Schultz-Cherry
Nov 15, 2013·Advances in Nutrition·Maria Carlota Dao, Simin Nikbin Meydani
Nov 21, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T PechtA Rudich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.