Increased testosterone levels and cortisol awakening responses in patients with borderline personality disorder: gender and trait aggressiveness matter

Psychoneuroendocrinology
Juliane RauschKatja Bertsch

Abstract

Borderline personality disorder (BPD) is characterized by antagonism, negative affectivity, disinhibition, and impairments in interpersonal functioning, including enhanced impulsive aggression. Interpersonal dysfunctions may be related to alterations in endocrine systems. The current study investigated alterations in basal activity of the hypothalamus-pituitary-gonadal (HPG) reproductive and the hypothalamus-pituitary-adrenal (HPA) stress system in BPD patients and their association to anger-related aggression with a particular focus on effects of gender and comorbid conditions of depression and posttraumatic stress disorder (PTSD). Saliva testosterone levels as well as cortisol awakening responses were assessed in 55 medication-free female and male patients with BPD and compared to 47 gender-, age-, and intelligence-matched healthy volunteers. In addition, analyses controlling for current depression and PSTD and bivariate correlations between testosterone and cortisol levels on the one hand and anger and aggressiveness on the other hand were performed. The results revealed increased saliva testosterone levels in female and male patients with BPD as well as elevated cortisol awakening responses in female, but not male patients ...Continue Reading

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Citations

Sep 8, 2016·Harvard Review of Psychiatry·Anthony C Ruocco, Dean Carcone
Sep 26, 2016·Psychoneuroendocrinology·Corinna ReichlMichael Kaess
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Feb 2, 2021·Borderline Personality Disorder and Emotion Dysregulation·Christian E DeuterKatja Wingenfeld
Aug 15, 2021·Journal of Neural Transmission·Juliane RauschKatja Bertsch

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