Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice

Brain : a Journal of Neurology
Michael SchroeterSebastian Jander

Abstract

Inflammation aggravates brain injury caused by stroke and neurodegeneration. Osteopontin (OPN) is a cytokine-like glycoprotein that binds to various integrins and CD44 variants. OPN exerts proinflammatory effects in autoimmune conditions but also has cytoprotective properties and participates in wound healing. In this study, we addressed the role of OPN in ischaemic brain injury using OPN knock-out (KO) mice in models of cortical stroke. Compared with wild-type animals, OPN KO mice exhibited unaltered infarct development at the primary injury site but greatly increased retrograde degeneration of the ipsilateral thalamus. Thalamic neurodegeneration in OPN-deficient mice was associated with pronounced microglia activation and inflammatory gene expression and could be attenuated via pharmacological blockade of the inducible nitric oxide synthase (iNOS). Therefore, delayed neurodegeneration in OPN-deficient mice was at least partly due to an excessive release of nitric oxide via the iNOS pathway. Neuroprotective and anti-inflammatory effects of OPN may be relevant for a variety of neurological disease conditions.

Citations

May 7, 2008·Journal of the Association for Research in Otolaryngology : JARO·Xing ZhaoYunxia Wang Lundberg
Feb 16, 2007·Neuroreport·Barnaby C L MarshDavid Wynick
Jun 5, 2008·Epilepsia·Karin BorgesRaymond Dingledine
Apr 13, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jang-Mi ParkMun-Yong Lee
Nov 21, 2015·Biochimica Et Biophysica Acta·Michael GliemSebastian Jander
Dec 4, 2014·Journal of Neuroinflammation·Anna-Maj AlbertssonXiaoyang Wang
Jun 19, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Li LingSuping Zhang
Nov 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jean-Claude BaronMatthias Endres
Oct 31, 2006·NeuroImage·Matthias L SchroeterD Yves von Cramon
Apr 29, 2010·British Journal of Pharmacology·S SorceK H Krause
Jun 5, 2010·The American Journal of Pathology·Walter MaetzlerCordula Nitsch
Feb 23, 2013·Molecular and Cellular Neurosciences·Hiroko Ikeshima-KataokaMasato Yasui
Aug 21, 2013·Journal of the Neurological Sciences·Song-Jie LiaoHai-Wei Huang
Aug 19, 2015·Frontiers in Cellular Neuroscience·Cedric Boeckx, Antonio Benítez-Burraco
Jul 3, 2015·Frontiers in Psychology·Antonio Benítez-Burraco, Cedric Boeckx
May 23, 2015·Stem Cell Research & Therapy·Monika RabensteinMaria Adele Rueger
May 9, 2013·Experimental Neurology·Masahiro TsujiTomohiro Matsuyama
May 14, 2016·Scientific Reports·Tomohiko OzakiToshihide Yamashita
Aug 10, 2016·Frontiers in Molecular Neuroscience·Seung Wook ChangIn-Beom Kim
Oct 12, 2016·Journal of Neuroimmunology·Monika RabensteinMaria Adele Rueger
Sep 28, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Budbazar EnkhjargalJohn H Zhang
Sep 12, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Murielle G KlugeFrederick R Walker
Feb 6, 2017·Circulation Research·Martin Dichgans, Didier Leys
Apr 12, 2012·Stroke; a Journal of Cerebral Circulation·Jian ZhangJinsheng Zeng
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·Sebastian JanderAndreas Saleh

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