PMID: 6974039May 15, 1981Paper

Increased therapeutic index using moderate dose methotrexate and leucovorin twice weekly vs. weekly high dose methotrexate-leucovorin in patients with advanced squamous carcinoma of the head and neck: a safe new effective regimen

Cancer
J M KirkwoodD Miller

Abstract

A new intensive methotrexate regimen for the treatment of advanced squamous carcinoma of the head and neck is presented, employing twice-weekly parenteral low-moderate doses of methotrexate and a single parenteral dose of leucovorin 24 hours following methotrexate. Toxicity and therapeutic results in 20 patients treated with this regimen favorably with results of weekly high-dose methotrexate-leucovorin in 36 patients treated immediately before initiation of the new regimen. Moderate nephrotoxicity and mild gastrointestinal/mucosal toxicity were common to both, while myelotoxicity was rarely seen with the low dose regimen and was more frequent with the high-dose regimen. Partial response was observed in 60% of patients treated on the intensive low-moderate dose schedule, and 50% of patients previously untreated with methotrexate on the weekly high-dose schedule. None of 12 patients previously failing low-moderate doses of methotrexate responded to high doses administered in this trial. The characteristics of antitumor response with low-moderate and high-dose schedules were similar except for the median dose required to attain response (50 mg/m2 vs. 3 g/m2) and the lesser toxicity of intensive lower dose therapy with leucovorin.

Citations

Jan 1, 1987·Cancer Metastasis Reviews·M Al-Sarraf
Jan 1, 1986·Cancer Chemotherapy and Pharmacology·D J StewartJ Gerin-Lajoie
Jun 1, 1994·Cancer Metastasis Reviews·B A Teicher
Jan 1, 1984·Breast Cancer Research and Treatment·G CocconiG Peracchia
Jul 15, 1988·Biochemical Pharmacology·B A Kamen, N J Winick
Nov 3, 1983·The New England Journal of Medicine·J JolivetB A Chabner
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E FreiW A Haseltine
Jan 16, 2015·International Journal of Molecular Sciences·Pamela T Wong, Seok Ki Choi
Jan 1, 1991·Cancer Investigation·O G Jonsson, B A Kamen
Jan 1, 1985·Cancer Investigation·R J Papac
Jun 1, 1986·The American Journal of the Medical Sciences·A A Forastiere
Dec 1, 1990·Experimental and Molecular Pathology·M G el-BadawiM A Abdalla
Mar 1, 1983·Cancer Treatment Reviews·J H Schornagel, J G McVie
Jan 1, 1988·Medical and Pediatric Oncology·M A EisenbergerM Friedman
Jan 1, 1984·Critical Reviews in Oncology/hematology·M Al-Sarraf
Jan 14, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Betty S ChanNicholas A Buckley
Jan 16, 2021·Cancer Cell·Liang ChangWilliam R Sellers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.