Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors.

Brain Research
Miao ShiFei Luo

Abstract

Clinical observations suggest that depressed patients were less sensitive to experimental pain than healthy subjects. However, few animal studies are reported concerning the association of depression and pain. The purpose of this study was to investigate the effects of unpredictable chronic mild stress (UCMS) induced depression on the perceived intensity of painful stimulation in rats. We measured the thermal and mechanical paw withdrawal thresholds (PWT) of normal and spinal nerve ligated (SNL) rats using hot plate test and von Frey test, respectively. The results showed that rats exposed to UCMS exhibited significantly higher thermal and mechanical pain thresholds in comparison to the non-depressed controls. In particular, the PWT of the SNL group was restored to nearly normal level after three weeks of UCMS, and even comparable to that of the control group. These results strongly suggest that the depressed subjects have decreased sensitivity to externally applied noxious stimulation, which is consistent with our previous findings.

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Citations

Aug 8, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ermelinda LomazzoBeat Lutz
Mar 4, 2014·Experimental Brain Research·Antonio Rodríguez-GaztelumendiAlvaro Díaz
Jul 15, 2015·Physiology & Behavior·Yan LiuYu-Qiu Zhang
Mar 28, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hye J JeonDong K Ahn
Jul 11, 2014·Progress in Neurobiology·Elaine M JenningsDavid P Finn
May 7, 2014·Behavioural Brain Research·Jun-Xu Li
Oct 14, 2016·Frontiers in Behavioral Neuroscience·Ning WangFei Luo
Sep 21, 2013·Cephalalgia : an International Journal of Headache·Chi-Han KaoJong-Ling Fuh
Jun 20, 2017·Neuropharmacology·Stephen G WoodhamsVolker Neugebauer
Jun 1, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Xinhe LiuFei Luo
May 22, 2020·Neuroscience and Biobehavioral Reviews·Lidia BravoEsther Berrocoso
Jun 21, 2014·Behavioural Pharmacology·Mariusz PappPaul Willner

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