Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children.

Pediatric Diabetes
Hildegard Jasser-NitscheAxel Schlagenhauf

Abstract

In type 1 diabetes (T1D), a prothrombotic status due to elevated coagulation factors coincides with metabolic derailment. In a previous study, we discovered altered thrombin generation profiles in children with T1D. These alterations are potentially most pronounced at T1D onset and ameliorated after insulin treatment. We tested this hypothesis in a longitudinal study, measuring thrombin generation together with coagulation parameters in children at T1D onset and during follow-up. Twenty-three children (12 female, age: 9.4 [2.7-17.3] years; median [range]) were tested at T1D onset and after long-term insulin treatment. Thrombin generation was measured using calibrated automated thrombography. Tissue factor (TF) activity and tissue factor pathway inhibitor (TFPI) activity were measured using enzyme-linked immunosorbent assay (ELISA). A procoagulant shift was observed in thrombin generation traces at T1D onset compared to follow-up (time to peak: 5.67 [4.11-7.67] min vs 6.39 [4.89-10.44] min, P < .001). These alterations at T1D onset coincided with increased TF activity (5.18 [0.01-12.97] pmol/L vs 2.67 [0.04-10.41] pmol/L, P < .05) and increased TFPI activity (0.051 [0.038-0.074] U/mL vs 0.035 [0.026-0.056] U/mL, P < .05). The pr...Continue Reading

References

Mar 22, 2001·Journal of Diabetes and Its Complications·M E Carr
Jul 11, 2003·Pathophysiology of Haemostasis and Thrombosis·H Coenraad HemkerSuzette Béguin
Nov 3, 2006·Thrombosis and Haemostasis·H Coenraad HemkerSuzette Béguin
Jul 25, 2007·Journal of Internal Medicine·P J Grant
Feb 28, 2008·Journal of Korean Medical Science·Seon Mi JinYong Soo Yun
May 26, 2009·Lancet·Kathleen M DunganJean-Charles Preiser
May 25, 2010·Journal of Thrombosis and Haemostasis : JTH·B A LemkesJ B L Hoekstra
Feb 11, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Darintr SosothikulPanya Seksarn
May 15, 2012·Journal of Thrombosis and Haemostasis : JTH·R LoeffenH ten Cate
Jan 11, 2013·Physiological Reviews·Josephine M Forbes, Mark E Cooper
Feb 9, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Thai Hoa TranAlik Kornecki
Jul 31, 2013·Lancet·Mark A AtkinsonAaron W Michels
Apr 9, 2014·Journal of Thrombosis and Haemostasis : JTH·J A TalaE V S Faustino
Nov 26, 2014·Journal of Thrombosis and Haemostasis : JTH·R M W KremersH C Hemker
Feb 17, 2015·World Journal of Diabetes·Shara R BialoJose Bernardo Quintos
Jun 3, 2016·Clinical Medicine : Journal of the Royal College of Physicians of London·Hayden WhiteMark Jones
Apr 15, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Jordan LoaderGuillaume Walther
Oct 28, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Cigdem BinayOlga Meltem Akay

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
blood draw

Software Mentioned

Thrombinoscope
Graphpad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

World Journal of Diabetes
Lara Frommer, George J Kahaly
Endocrinology and Metabolism Clinics of North America
David M MaahsElizabeth J Mayer-Davis
Boletín médico del Hospital Infantil de México
María E Mejía-León, Ana María Calderón de la Barca
© 2021 Meta ULC. All rights reserved