PMID: 2492837Jan 1, 1989Paper

Increased tissue-plasminogen activator (t-PA) levels in patients under oral anticoagulant therapy

Blut
J Grulich-HennG Müller-Berghaus

Abstract

The fibrinolytic system was investigated in 30 patients under oral anticoagulant therapy, and in 23 control patients not receiving oral anticoagulants. Patients under oral anticoagulant therapy had significantly higher tissue-plasminogen activator (t-PA) antigen levels than patients in the control group. Mean t-PA levels before venous occlusion were 18.4 ng/ml in the anticoagulated patients vs. 7.9 ng/ml in the control patients (p less than 0.001). After venous occlusion for 10 minutes, t-PA levels were 45.0 ng/ml in the anticoagulated patients and 24.2 ng/ml in the control patients (p less than 0.01). Plasminogen activator inhibitor (PAI) capacity was not significantly different in the two groups before venous occlusion (VO) but differed slightly (p less than 0.05) after VO. The net decrease in euglobulin lysis time (ELT) after venous occlusion (= ELT before VO - ELT after VO), indicating the relative potency of the fibrinolytic activity in blood, was also significantly higher in the anticoagulated patients (median 240 min vs. 125 min, p less than 0.001). These data indicate that oral anticoagulant therapy increases the fibrinolytic activity in blood, and thus may have an additional therapeutic effect in addition to anticoagul...Continue Reading

References

Nov 17, 1977·The New England Journal of Medicine·T C ChalmersA M Kunzler
Feb 15, 1986·Thrombosis Research·C KorningerB R Binder
Jun 1, 1987·Thrombosis Research·Y HashimotoA Takada
Dec 15, 1987·Thrombosis Research·T K Nilsson, O Johnson
Mar 1, 1986·Blut·W ThielG Müller-Berghaus
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y SakataD J Loskutoff
May 1, 1972·Journal of Applied Physiology·W Van Beaumont
Mar 1, 1971·Stroke; a Journal of Cerebral Circulation·C H Millikan
Nov 1, 1981·The Journal of Clinical Investigation·P C Comp, C T Esmon
May 1, 1959·Journal of Clinical Pathology·E KOWALSKI NIEWIAROWSKI

❮ Previous
Next ❯

Citations

May 1, 1990·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C SchubringG Müller-Berghaus
Mar 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C SchubringG Müller-Berghaus
Apr 14, 2011·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Umit KocMusa Akoglu
Jan 1, 1994·Journal of Biomaterials Science. Polymer Edition·T GrothG Altankov
Dec 1, 1989·Thrombosis Research·P Klein
May 1, 1992·Progress in Cardiovascular Diseases·J FareedR Pifarre
Nov 6, 1998·Stroke; a Journal of Cerebral Circulation·B KristensenT Olsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.