PMID: 9184810May 1, 1997Paper

Increased toxicity of methamphetamine in morphine-dependent mice

General Pharmacology
O T GinawiS A Bakheet

Abstract

1. The effect of methamphetamine on morphine-dependent mice was investigated by calculating the LD50 (i.p.), measuring motor activity, anorectic actions, and body temperature. 2. Methamphetamine was more toxic in morphine-dependent mice (LD50 = 20.6 mg/kg) than in normal mice (LD50 = 43.2 mg/kg). 3. Methamphetamine-induced locomotor activity was greater in morphinized than in nonmorphinized mice at doses of 2.5 and 5 mg/kg i.p. 4. Methamphetamine also increased the body temperature of morphinized mice more than that of normal mice (P < 0.05). 5. These findings suggest that methamphetamine is more toxic in morphine-dependent than in nondependent mice.

References

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Citations

May 10, 2011·Pharmacology, Biochemistry, and Behavior·Keith A TrujilloMelissa M Guaderrama
May 26, 2016·Journal of Psychoactive Drugs·Alethea DesrosiersMarek C Chawarski
Nov 5, 2020·Journal of Economic Entomology·David L FindleyMichael D Hambuchen

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