Increased transcription of immune and metabolic pathways in naive and allergic mice exposed to diesel exhaust

Toxicological Sciences : an Official Journal of the Society of Toxicology
Tina StevensM Ian Gilmour

Abstract

Diesel exhaust (DE) has been shown to enhance allergic sensitization in animals following high-dose instillation or chronic inhalation exposure scenarios. The purpose of this study was to determine if short-term exposures to diluted DE enhance allergic immune responses to antigen, and identify possible mechanisms using microarray technology. BALB/c mice were exposed to filtered air or diluted DE to yield particle concentrations of 500 or 2000 mug/m(3) 4 h/day on days 0-4. Mice were immunized intranasally with ovalbumin (OVA) antigen or saline on days 0-2, challenged on day 18 with OVA or saline, and all mice were challenged with OVA on day 28. Mice were necropsied either 4 h after the last DE exposure on day 4, or 18, 48, and 96 h after the last challenge. Immunological endpoints included OVA-specific serum IgE, biochemical and cellular profiles of bronchoalveolar lavage (BAL), and cytokine production in the BAL. OVA-immunized mice exposed to both concentrations of DE had increased eosinophils, neutrophils, lymphocytes, and interleukin-6 (high dose only) post-challenge compared with OVA control, whereas DE/saline exposure yielded increases in neutrophils at the high dose only. Transcriptional microarray analysis 4 h after the l...Continue Reading

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Citations

Feb 16, 2010·Journal of Toxicology and Environmental Health. Part a·Jedd M HillegassBrooke T Mossman
Dec 17, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tina StevensM Ian Gilmour
Jan 30, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Brooke L HeidenfelderJane E Gallagher
Nov 11, 2011·American Journal of Respiratory and Critical Care Medicine·Terry L NoahIlona Jaspers
Jan 24, 2009·Environmental Health Perspectives·Reddy R GottipoluUrmila P Kodavanti
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Oct 10, 2013·Environmental and Molecular Mutagenesis·Esra MutluDavid M Demarini
Apr 27, 2018·Environmental Science and Pollution Research International·Joshua B LewisPaul R Reynolds
Jan 1, 2010·Biomedical Informatics Insights·Tina StevensM Ian Gilmour
Nov 24, 2020·Journal of Neuroinflammation·Hendrik J GreveMichelle L Block

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