Increased transcription of TSPO, HDAC2, and HDAC6 in the amygdala of males with alcohol use disorder.

Brain and Behavior
Luana Martins De CarvalhoNora D Volkow

Abstract

Repeated exposure to high doses of alcohol triggers neuroinflammatory processes that contribute to craving and mood dysfunction in alcohol use disorder (AUD). The upregulation of the translocator protein (TSPO) is considered a biomarker of neuroinflammation, and TSPO ligands have been used as neuroimaging biomarkers of neuroinflammation. Epigenetic mechanisms are also implicated in neuroinflammatory responses to alcohol, and elevated expression of HDAC2 and HDAC6 has been reported in the brain of animals exposed to chronic alcohol. The present study examined the transcriptional regulation of TSPO, HDAC2, and HDAC6 in human postmortem brain tissue from males previously diagnosed with AUD (n = 11) compared to age-matched nondependent males (n = 13) in four brain regions relevant to AUD: prefrontal cortex (PFC), nucleus accumbens (NAc), hippocampus (HPP), and amygdala (AMY). Translocator protein mRNA levels in AMY and PFC and HDAC2 and HDAC6 mRNA levels in AMY were upregulated in AUD compared to controls. In AMY, TSPO mRNA levels were positively associated with HDAC2 and HDAC6 mRNA levels, suggesting a possible regulation of TSPO by HDAC2 and HDAC6 in this brain region. In contrast, there were no group differences for TSPO, HDAC2,...Continue Reading

References

Sep 1, 1980·The Australian and New Zealand Journal of Psychiatry·D G LambieE A Whiteside
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 28, 2002·Journal of Addictive Diseases·Lance P LongoSandra Hubatch
Jul 20, 2002·Drug and Alcohol Dependence·Kathleen T BradyScott F Coffey
Apr 10, 2007·Journal of Molecular Neuroscience : MN·Ron S BroideChristopher J Winrow
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Subhash C PandeyAnand Prakash
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Nora D Volkow
Nov 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mark A RivieccioBrett Langley
Dec 2, 2010·Nature Reviews. Drug Discovery·Rainer RupprechtMichael Schumacher
May 17, 2011·Trends in Immunology·Melanie R ShakespearMatthew J Sweet
Oct 13, 2011·Nature Reviews. Neuroscience·Alfred J Robison, Eric J Nestler
Nov 16, 2011·Immunology and Cell Biology·Bandar Ali SulimanBryan R G Williams
Feb 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Igor PonomarevR Dayne Mayfield
May 21, 2013·Journal of Neuroscience Research·Vishnu KannanHendrikus W G M Boddeke
Aug 12, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fengdong ChengEduardo M Sotomayor
Oct 28, 2014·Brain Pathology·Guo-Jun LiuRichard B Banati
Dec 3, 2014·Molecular Psychiatry·S P FarrisR D Mayfield
Aug 1, 2016·The Lancet. Psychiatry·George F Koob, Nora D Volkow
Nov 18, 2016·Scientific Reports·Rasmus RydbirkTomasz Brudek
Feb 6, 2017·Neuropharmacology·Fulton T CrewsLeon G Coleman
Feb 9, 2017·Neuropharmacology·Subhash C PandeyHuaibo Zhang
May 10, 2017·Alcohol·Martina Palmisano, Subhash C Pandey
Nov 9, 2017·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Matthew Neal, Jason R Richardson
Mar 10, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John Peyton BohnsackA Leslie Morrow
Mar 27, 2018·Journal of Cellular Physiology·Maria G DaskalakiSotirios C Kampranis
May 20, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sung Won KimNora D Volkow
Nov 10, 2018·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Khalid RashidThomas Langmann
Jul 1, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wen-Bin ZhangZuo-Jiong Gong
Jul 23, 2019·The Journal of Clinical Investigation·Katarzyna PlacekAnna C Aschenbrenner
Mar 7, 2020·Human Molecular Genetics·Eric BrennerR Dayne Mayfield

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Citations

Aug 4, 2021·Brain, Behavior, and Immunity·Lindsay R MeredithLara A Ray
Aug 17, 2021·Brain Communications·Anastasia LanquetinAnne-Lise Pitel

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Methods Mentioned

BETA
sedation
histone acetylation
PCR

Software Mentioned

SPSS Statistics
GraphPad Prism

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