Increased transendothelial permeation of albumin by high glucose concentration

Metabolism: Clinical and Experimental
T YamashitaH Nawata

Abstract

Vascular endothelial cells, which are polyfunctional, play an important role in the pathogenesis of diabetic complications. The increase in vascular permeability, ie, regulated by vascular endothelial cells, has been reported in patients with diabetes mellitus complicated by angiopathy. To determine the role of hyperglycemia in endothelial cell permeability, we examined the effect of high concentrations of glucose on the permeability of cultured bovine aortic endothelial cells. The permeations of albumin and fluorescein-labeled dextran (FD) across endothelial cell monolayers were increased when cultured with a high concentration of glucose (400 mg/dL). This increased permeation of albumin but not FD was temperature-dependent and was partially reduced by adding 100 mumol/L ponalrestat (ICI 128,436, Statil; ICI, Cheshire, UK), which is an aldose reductase inhibitor. Stimulation or inhibition of Na,K-adenosine triphosphatase (ATPase) in bovine aortic endothelial cells failed to alter their permeability. These findings suggest that high concentrations of glucose enhance transendothelial permeability of albumin in part by activating the polyol pathway, but independently of Na,K-ATPase activity.

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Citations

Feb 5, 2003·Canadian Journal of Physiology and Pharmacology·Bryan SimardPierre Sirois
Feb 16, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mehmet KayaImdat Elmas
Jan 30, 2014·Biochemical and Biophysical Research Communications·M Elizabeth MeredithJames M May
Jul 1, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jisun PaengShin-Wook Kang
Jul 28, 2005·Journal of the Society for Gynecologic Investigation·Heinz LeipoldElisabeth Krampl
Mar 20, 2010·American Journal of Physiology. Renal Physiology·Josefin AxelssonBengt Rippe

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