Aerobic gram-negative bacilli and other indigenous gastrointestinal (GI) bacteria are important opportunistic pathogens in immunosuppressed cancer patients. These same bacteria frequently translocate from the GI tracts of mice immunosuppressed by single injections of certain anticancer drugs or by T-lymphocyte impairments. Since similar cellular and humoral immune deficiencies may be present in the tumor-bearing host, we sought to determine if progressive growth of a tumor alone would be sufficient to enhance the translocation of indigenous bacteria from the murine GI tract. Pathogen-free DBA/2 mice were injected intraperitoneally with 10(6) viable sarcoma 180 (S-180) cells or 0.5 ml of sterile buffer. Mesenteric lymph nodes, livers, spleens, and kidneys were tested for the presence of translocated aerobic GI bacteria on various days after tumor injection. Immunity was assessed by measuring footpad delayed-type hypersensitivity and serum hemagglutinins to sheep erythrocytes. Overall, translocated aerobic GI bacteria infected 33 of 92 S-180-bearing mice (36%) and only 9 of 99 control mice (9%) (P less than 10(-6)). Cumulatively, 50 of 460 sites (10.9%) in S-180-bearing mice were infected with translocated GI bacteria as opposed ...Continue Reading
Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model.
Inhibition of translocation of viable Escherichia coli from the gastrointestinal tract of mice by bacterial antagonism.
Relationship between cecal population levels of indigenous bacteria and translocation to the mesenteric lymph nodes.
Inhibition of Escherichia coli translocation from the gastrointestinal tract by normal cecal flora in gnotobiotic or antibiotic-decontaminated mice.
Promotion of the translocation of enteric bacteria from the gastrointestinal tracts of mice by oral treatment with penicillin, clindamycin, or metronidazole.
Infections in compromised hosts: modified susceptibility of tumor-bearing mice to experimental infection with Proteus morganii strain 1510
Infection prevention during profound granulocytopenia. New approaches to alimentary canal microbial suppression
Impaired resistance to bacterial infection after tumor implant is traced to lactic dehydrogenase virus.
Transmural migration of intestinal bacteria; a study based on the use of radioactive Escherichia coli
Effects of a water-soluble ethylhydroxyethyl cellulose on gut physiology, bacteriology, and bacterial translocation in acute liver failure
N-acetylcysteine reduces respiratory burst but augments neutrophil phagocytosis in intensive care unit patients
Relations among circulating monocytes, dendritic cells, and bacterial translocation in patients with intestinal obstruction.
Distribution of pathogens in central line-associated bloodstream infections among patients with and without neutropenia following chemotherapy: evidence for a proposed modification to the current surveillance definition
The analysis of the defense mechanism against indigenous bacterial translocation in X-irradiated mice
Glutamine-supplemented tube feedings versus total parenteral nutrition in children receiving intensive chemotherapy
Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study
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