Increased translocation of bacteria from the gastrointestinal tracts of tumor-bearing mice.

Infection and Immunity
R L PennR D Berg

Abstract

Aerobic gram-negative bacilli and other indigenous gastrointestinal (GI) bacteria are important opportunistic pathogens in immunosuppressed cancer patients. These same bacteria frequently translocate from the GI tracts of mice immunosuppressed by single injections of certain anticancer drugs or by T-lymphocyte impairments. Since similar cellular and humoral immune deficiencies may be present in the tumor-bearing host, we sought to determine if progressive growth of a tumor alone would be sufficient to enhance the translocation of indigenous bacteria from the murine GI tract. Pathogen-free DBA/2 mice were injected intraperitoneally with 10(6) viable sarcoma 180 (S-180) cells or 0.5 ml of sterile buffer. Mesenteric lymph nodes, livers, spleens, and kidneys were tested for the presence of translocated aerobic GI bacteria on various days after tumor injection. Immunity was assessed by measuring footpad delayed-type hypersensitivity and serum hemagglutinins to sheep erythrocytes. Overall, translocated aerobic GI bacteria infected 33 of 92 S-180-bearing mice (36%) and only 9 of 99 control mice (9%) (P less than 10(-6)). Cumulatively, 50 of 460 sites (10.9%) in S-180-bearing mice were infected with translocated GI bacteria as opposed ...Continue Reading

References

Sep 1, 1972·Applied Microbiology·P B SmithA Balows
Feb 1, 1980·Infection and Immunity·W E Owens, R D Berg
Oct 1, 1982·Nihon juigaku zasshi. The Japanese journal of veterinary science·K KawaharajoY Sekizawa
Jul 1, 1965·The Journal of Experimental Medicine·R W SCHAEDLERR COSTELLO
May 11, 1950·The New England Journal of Medicine·F B SCHWEINBURGJ FINE

❮ Previous
Next ❯

Citations

Jan 1, 1995·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·X WangR Andersson
Jan 9, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·James P SteinbergJesse T Jacob
Mar 30, 2013·Infectious Agents and Cancer·Joanne Cummins, Mark Tangney
Apr 1, 1997·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·C FordJ B Pietsch
Jun 3, 2015·Infection and Immunity·Sabrina I GreenAnthony W Maresso
Jan 24, 2007·Diseases of the Colon and Rectum·Kin F ChinJohn MacFie
May 30, 1998·Acta Anaesthesiologica Scandinavica·A HellerT Koch
Jan 11, 2021·Trends in Immunology·Alex C McPhersonMarlies Meisel
Aug 1, 1997·The Journal of Surgical Research·M DoğanayA Tekeli
Feb 1, 1995·Journal of Pediatric Surgery·R T MaxsonS D Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.