PMID: 8588337Nov 1, 1995Paper

Increased tumor necrosis factor-alpha and interleukin-1 beta expression in the lungs of calves with experimental pneumonic pasteurellosis

Veterinary Immunology and Immunopathology
H S YooM Suresh

Abstract

We used a well characterized pneumonic pasteurellosis model in calves to determine whether increased proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) expression and secretion were associated with pneumonic lesions. Bronchoalveolar lavage fluids, lavage cells consisting of alveolar macrophages and neutrophils with degenerative changes, and lung tissues were analyzed for the presence of TNF-alpha and IL-1 beta approximately 48 h following endobronchial inoculation of logarithmic phase Pasteurella haemolytica 12296 organisms. Levels of TNF-alpha and IL-1 beta mRNA were significantly increased in lavage cells of P. haemolytica-infected animals but not in cells from phosphate buffered saline (PBS) inoculated controls based on in situ hybridization analysis. Significantly increased levels of TNF-alpha, and IL-1 beta mRNA were also expressed within the pneumonic lesions from P. haemolytica-infected calves. In contrast, lung tissues from PBS-inoculated control calves had cytokine mRNAs expressed at extremely low levels. Increased levels of bioactive IL-1 and immunoreactive (not bioactive) TNF-alpha were found in lavage fluids from P. haemolytica-infected calves compared with lavage f...Continue Reading

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Citations

Jan 8, 1999·Veterinary Immunology and Immunopathology·G IovaneA Marcatili
Sep 1, 2000·Microbes and Infection·M R Ackermann, K A Brogden
Mar 23, 2012·Veterinary Research·Paul D HodgsonPhilip J Griebel
Oct 11, 2001·American Journal of Veterinary Research·G H LoneraganL J Mills
Nov 15, 2006·Journal of Comparative Pathology·J C Hodgson
Sep 19, 2002·The Journal of Veterinary Medical Science·Hajime NagahataHiroshi Iwai
Jun 1, 1997·The Journal of Veterinary Medical Science·M GotoH Iwai
Apr 20, 2006·Veterinary Immunology and Immunopathology·Donna P RogersDerek A Mosier
Apr 14, 2006·Veterinary Research·Eileen L Thacker
Jan 3, 2014·TheScientificWorldJournal·Ashok K BalharaInderjeet Singh
Jan 1, 1997·Veterinary Clinical Pathology·Javed RashidRonald Bach
Dec 31, 1997·The Journal of Veterinary Medical Science·H OhtsukaT O Yoshino
Oct 21, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Baljit SinghSarah Caldwell

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