Increased tumor necrosis factor-alpha concentrations with interleukin-4 concentrations in exacerbations of schizophrenia

Psychiatry Research
Sinead M O'BrienTimothy G Dinan

Abstract

Several studies have indicated that cytokines may be involved in the pathophysiology of schizophrenia. Previous studies, however, have yielded contradictory results; in this study we assess the plasma levels of both T-helper-1 (Th1) and T-helper-2 (Th2) cytokines in patients with acute exacerbations of schizophrenia. Plasma concentrations of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha) and soluble receptor of interleukin-6 (sIL-6R) were measured with high sensitivity, enzyme-linked immunosorbent assays (ELISA) in patients with acute exacerbations of schizophrenia as compared with healthy controls. Patients with an acute exacerbation of schizophrenia had significantly increased production of TNF-alpha and significantly reduced production of IL-4 as compared with healthy subjects. No significant difference was observed in IL-6, sIL-6R, IL-8 and IL-10. Acute exacerbations of schizophrenia are associated with increased TNF-alpha concentrations (Th1) with concomitantly reduced concentrations of IL-4 (Th2) and a resulting increased TNF-alpha/IL-4 ratio.

References

Aug 1, 1992·The Journal of Clinical Investigation·S LacrazH G Welgus
Apr 1, 1991·Archives of General Psychiatry·E Van CauterJ Mendlewicz
Mar 1, 1991·The Journal of Experimental Medicine·E P SampaioG Kaplan
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1983·Schizophrenia Bulletin·J C Garbutt, D P van Kammen
Nov 1, 1995·The Journal of Clinical Investigation·S LacrazJ M Dayer
Feb 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·H M XuG P Hemmings
Jul 5, 1996·Schizophrenia Research·J NaudinD Dassa
Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·I WilkeH Kirchner
Jan 1, 1997·European Archives of Psychiatry and Clinical Neuroscience·U H FrommbergerM Berger
May 16, 1998·Biological Psychiatry·Y K KimK Y Suh
Jul 2, 1998·Neuropsychobiology·M RothermundtH Kirchner
Jan 27, 1999·Journal of the American Geriatrics Society·A N DentinoH J Cohen
Dec 1, 1999·Inflammatory Bowel Diseases·S Romagnani
Mar 9, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M MaesC A Altamura
Jan 12, 2001·Clinical and Experimental Pharmacology & Physiology·B J Mowry, D J Nancarrow
Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Carlo L CazzulloMario Clerici
Mar 27, 2002·The International Journal of Neuroscience·D J KimY K Kim
Mar 29, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Alan S Brown, Ezra S Susser
Jul 2, 2002·The American Journal of Psychiatry·Mary CannonRobin M Murray
Aug 9, 2002·The Journal of International Medical Research·S EbrinçM Cetin
Dec 6, 2002·The International Journal of Neuropsychopharmacology·Gunter Kenis, Michael Maes
Jul 18, 2003·Current Diabetes Reports·Waleed Aldhahi, Osama Hamdy
Aug 30, 2003·Current Pain and Headache Reports·Mollie E Thompson, André Barkhuizen
Jan 6, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J S Yudkin
May 4, 2004·The American Journal of Psychiatry·Alan S BrownEzra S Susser
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong-Ku KimBrian E Leonard
Jan 22, 2005·Psychiatry Research·Yong-Ku KimHarry W M Steinbusch
Aug 30, 2005·Journal of Affective Disorders·Aye-Mu MyintYong-Ku Kim
Feb 14, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Se-Ran YangIrfan Rahman
Mar 1, 2006·International Immunopharmacology·Chi-Un PaeIn-Ho Paik
Jun 17, 2006·Biochimica Et Biophysica Acta·Loutfig DemirjianVincent Duronio

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Citations

Sep 8, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Feng-Shiun ShieIng-Kang Ho
Jan 30, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Natalya A UranovaDiana D Orlovskaya
Feb 22, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rachel E Kneeland, S Hossein Fatemi
Jan 14, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Haruhiko SuginoYoshinori Marunaka
Sep 27, 2015·Brain, Behavior, and Immunity·Xiang Yang ZhangJair C Soares
May 26, 2012·Psychiatry and Clinical Neurosciences·Rodrigo Barbachan MansurElisa Brietzke
Jul 7, 2010·Psychiatry and Clinical Neurosciences·Yuichiro WatanabeHiroyuki Nawa
Jun 7, 2011·Biological Psychiatry·Brian J MillerBrian Kirkpatrick
Jan 10, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Fan WangXiang Yang Zhang
Jan 28, 2014·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Md Mamun Al-AminHasan Mahmud Reza
May 20, 2011·Journal of Psychiatric Research·Hubertus HimmerichUlrich Sack
Jan 21, 2015·Schizophrenia Research·Hui-Mei AnXiang Yang Zhang
Jan 25, 2011·The International Journal of Neuropsychopharmacology·Roosmarijn C DrexhageHemmo A Drexhage
Dec 3, 2014·Psychiatry Research·Yousri El KissiJalel Boukadida
Jul 8, 2016·Journal of Child and Adolescent Psychopharmacology·Şeref ŞimşekSavaş Kaya
Sep 22, 2016·Schizophrenia Research·Suzi HongDilip V Jeste
Oct 5, 2016·Journal of Psychiatric Research·Tatiane da Silva AraújoDanielle Macêdo
Nov 5, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·R BalõtševE Vasar
Nov 23, 2017·Frontiers in Psychiatry·Milica Milovan BorovcaninMiodrag L Lukic
Oct 21, 2017·Molecular Neurobiology·G MorrisB K Puri
Aug 10, 2012·Journal of Leukocyte Biology·Wouter BeumerHemmo A Drexhage
Dec 22, 2009·Expert Review of Neurotherapeutics·Roosmarijn C DrexhageHemmo A Drexhage
Jan 25, 2012·European Archives of Psychiatry and Clinical Neuroscience·Daniela L KrauseNorbert Müller
Jun 26, 2018·Frontiers in Neuroscience·Md Mamun Al-AminHasan Mahmud Reza
Dec 19, 2018·Cellular and Molecular Neurobiology·Mohammad Reza SafariSoudeh Ghafouri-Fard

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