PMID: 11341972May 9, 2001Paper

Increased uncoupling protein-2 gene expression in brain of lipopolysaccharide-injected mice: role of tumour necrosis factor-alpha?

Biochimica Et Biophysica Acta
S BusquetsJ M Argilés

Abstract

In order to understand the role of brain localized uncoupling proteins, we have examined the UCP2 and BMCP-1 gene expression in mice brain in two different catabolic states: administration of lipopolysaccharide (LPS) (2.5 mg/kg, i.p.) and tumour burden. Administration of LPS resulted in an increased UCP2 gene expression both in brain (208%) and cerebellum (77%). An increase in UCP2 gene expression was also observed after LPS treatment in double knockout mice for tumour necrosis factor-alpha (TNF) receptors 1 and 2 (75% in brain and 33% in cerebellum). Tumour growth also resulted in increased brain UCP2 gene expression (80%) in mice bearing the Lewis lung carcinoma as compared with the non-tumour-bearing controls. No changes were observed in BMCP-1 mRNA levels of either LPS-injected or tumour-bearing mice. From the results presented it may be suggested that: (a) the brain may contribute significantly to the increase in energy expenditure associated with hypermetabolic states such as fever and tumour burden, and (b) the regulation of UCP2 gene expression in brain does not seem to be influenced by TNF; therefore the action of other cytokines cannot be discarded.

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Citations

Jun 11, 2002·Biochemical and Biophysical Research Communications·Josep M ArgilésFrancisco J López-Soriano
Jul 20, 2002·The International Journal of Biochemistry & Cell Biology·Petr Jezek
Aug 24, 2005·Antioxidants & Redox Signaling·Jeong Sook Kim-Han, Laura L Dugan
Feb 21, 2006·Antioxidants & Redox Signaling·Gustav Mattiasson, Patrick G Sullivan
Feb 8, 2005·The International Journal of Biochemistry & Cell Biology·Michal RůzickaPetr Jezek
Aug 15, 2014·Journal of Cachexia, Sarcopenia and Muscle·Josep M ArgilésSílvia Busquets
Oct 9, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alexander JacobJessy J Alexander
Apr 1, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·L LiG E Isom
Sep 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Justin D EllettKenneth D Chavin
Jul 11, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Wolfgang Langhans

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