PMID: 9165295Jan 1, 1997Paper

Increased uptake of LDL by oxidized macrophages is the result of an initial enhanced LDL receptor activity and of a further progressive oxidation of LDL

Free Radical Biology & Medicine
B FuhrmanM Aviram

Abstract

Iron ions were recently shown to induce cellular lipid peroxidation in macrophages, and these oxidized cells can convert native low-density lipoprotein (LDL) to oxidized LDL (Ox-LDL). The present study demonstrates that deoxycholic acid (DCA) and angiotensin II (ANG-II) can also induce oxidative modification of macrophages via metal ions independent mechanisms. Furthermore, incubation of LDL (200 micrograms of protein/ml) for 24 h at 37 degrees C with DCA, ANG-II, as well as FeSO4-induced oxidized macrophages, resulted in oxidative modification of the lipoprotein as evidenced by increased TBARS formation in LDL (by 50, 105, and 258%, respectively), decreased TNBS reactivity (by 45, 56, and 42%, respectively), and increased cellular uptake (by 60, 166, and 230%, respectively). A positive correlation (n = .88) was found between the extent of the cellular lipid peroxidation and the increment in the cellular uptake of the LDL. The oxidative modification of LDL by oxidized macrophages was found to be a progressive process. Incubation of LDL with oxidized macrophages for increasing periods of time up to 24 h resulted in progressive increment in: (1) the electrophoretic mobility of the LDL; (2) the TBARS formation in LDL; (3) the cell...Continue Reading

References

Jan 1, 1978·Biochemical Pharmacology·Y Masuda, T Murano
Jan 1, 1979·Methods in Enzymology·M K Patterson
Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Apr 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S KeidarM Aviram
Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J Oiknine, M Aviram
May 29, 1992·Biochemical and Biophysical Research Communications·M Aviram, I Maor
Dec 1, 1991·The Journal of Clinical Investigation·J L Witztum, D Steinberg
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J de GraafA F Stalenhoef
Jan 1, 1990·Free Radical Biology & Medicine·U P SteinbrecherM Lougheed
Apr 1, 1990·The Journal of Clinical Investigation·J A BerlinerA M Fogelman
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W PalinskiJ L Witztum
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A G SuitsJ W Heinecke
Oct 1, 1989·The Journal of Clinical Investigation·S Ylä-HerttualaD Steinberg
Mar 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·U P SteinbrecherD Steinberg
Mar 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M F Lopes-VirellaH C Stevenson
Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·P AvogaroG Cazzolato
Sep 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S ParthasarathyD Steinberg
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·I TabasA R Tall
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M E HaberlandP A Edwards
Jan 1, 1983·Annual Review of Biochemistry·M S Brown, J L Goldstein
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·U P SteinbrecherD Steinberg
Sep 17, 1994·Lancet·J L Witztum
Oct 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S KiechlJ Willeit
Jun 1, 1994·Kidney International·D C WheelerJ D Williams
May 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R J SokolK O'Brien
Apr 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R E PouponG Paumgartner

❮ Previous
Next ❯

Citations

Apr 27, 1999·Atherosclerosis·M AviramP F Hollenberg
Sep 1, 1999·Kidney International·M BoazS Smetana
Oct 4, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kyung-Hyun Cho
Dec 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Michael Aviram, Mira Rosenblat
Jun 17, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tatsuya TagawaKotaro Takeda
Oct 12, 2000·Biochemical and Biophysical Research Communications·H ChenJ L Mehta
Aug 5, 2006·Pharmacogenomics·Nasséra ChalabiDominique Bernard-Gallon
Nov 6, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seon Beom KimMi Kyeong Lee
Dec 6, 2011·Atherosclerosis·Bianca Fuhrman
Sep 3, 2013·Biochemical and Biophysical Research Communications·Marie Koren-GluzerTony Hayek
Aug 24, 2005·The Journal of Nutritional Biochemistry·Bianca FuhrmanMichael Aviram
Jun 21, 2002·Annals of the New York Academy of Sciences·Michael Aviram, Bianca Fuhrman
Mar 17, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M D CarvalhoE C Quintão
Apr 26, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Bianca FuhrmanMichael Aviram
Feb 15, 2001·Current Opinion in Lipidology·B Fuhrman, M Aviram
Aug 7, 2019·International Journal of Molecular Sciences·Antoni PaulYoung-Hwa Goo
Sep 30, 2004·Free Radical Biology & Medicine·Michael Aviram, Mira Rosenblat

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.