PMID: 1866389Apr 1, 1991

Increased urinary calcium and magnesium excretion in rats injected with mercuric chloride

Pharmacology & Toxicology
X Y LiuG F Nordberg

Abstract

Mercuric chloride (HgCl2) is a classic nephrotoxic agent. While it is well established that HgCl2 can induce metallothionein synthesis in the kidney and also cause damage to the pars recta region of the renal tubule, the urinary losses of essential elements like calcium (Ca) and magnesium (Mg) probably related to this process, have not been described. In this study, calcium, magnesium, metallothionein (MT), as well as sodium (Na) and potassium (K) in urine, kidney cortex and liver were measured in male Wistar rats after two daily injections of HgCl2 (0.5 or 1.0 mg Hg/kg body weight intraperitoneally). As compared with controls, there was a significant 3-4-fold increase in calcium excretion which reached its maximum at 8-12 and 32-36 hr after treatment with 1.0 mg Hg/kg. Urinary magnesium excretion was also increased in a similar way as the calcium excretion. At 12-16 hr, urinary magnesium in the 1.0 mg Hg/kg dose group was 3.4 times higher than that of the controls. Urinary MT level in HgCl2 treated rats was much higher than that in the controls, the maximum excretion was between 24-28 and 32-36 hrs preceeded by the peak of Hg in urine. Na and K concentrations in urine decreased significantly in rats treated with HgCl2. The pre...Continue Reading

References

Nov 12, 1987·Biochimica Et Biophysica Acta·M W SmithB F Trump
Jan 1, 1987·Bulletin of Environmental Contamination and Toxicology·R K Zalups, G L Diamond
Apr 1, 1970·The Transactions of the Society of Occupational Medicine·G Kazantzis
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Citations

Jan 1, 1997·Pharmacology & Toxicology·D J SánchezJ L Domingo
Jan 1, 1992·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·X LiuT Jin
May 8, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Tatjana OrctMaja Blanuša

Related Concepts

Calcium
Diuresis
Structure of Cortex of Kidney
Liver
Magnesium
Mercuric chloride
Metallothionein IIA
Natriuresis
Potassium
Proteinuria

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