PMID: 6407299Jul 1, 1983Paper

Increased urinary excretion and prolonged turnover time of folic acid during ethanol ingestion

The American Journal of Clinical Nutrition
R M RussellA W Press

Abstract

The effect of ethanol on the kinetics of folic acid urinary excretion was studied in five chronic alcoholic patients who were maintained in a folate replete state. For 17 days, 95% ethanol was administered orally at 2-h intervals (X9). The folate pool(s) were labeled with the tritium labeled pteroyl glutamic acid at the start of the period of ethanol ingestion and at the start of a control abstinent period. The 24-h urine volume did not change with consumption of ethanol. Total urinary folate excretion was significantly greater by 20 to 40% in four of five patients during the ethanol administration period (p less than 0.05). The fall-off in urinary radioactivity corrected for total folate excretion (dpm/microgram Lactobacillus casei folate) was resolved into a biexponential decay with two distinct slopes. Ethanol caused the slope of the second component to flatten significantly with mean t1/2 of 63.7 days on ethanol versus 9.6 days off (p less than 0.05). These kinetic results are consistent with the known interference by ethanol of folate utilization in a functional tissue pool.

Citations

Aug 1, 1992·Alcoholism, Clinical and Experimental Research·T D CollinsK E McMartin
Apr 1, 1994·Alcoholism, Clinical and Experimental Research·R T Muldoon, K E McMartin
Mar 1, 1997·International Journal of Food Sciences and Nutrition·R M WeggemansJ Haller
Jun 11, 2002·Annual Review of Nutrition·Jesse F Gregory, Eoin P Quinlivan
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Charles H HalstedS Jill James
Feb 27, 2004·Addiction·Katherine M ConigraveJohn B Whitfield
Aug 20, 2008·Food and Nutrition Bulletin·Lindsay H Allen
Aug 7, 2002·The Journal of Nutrition·Charles H HalstedCarol J Chandler
Aug 7, 2013·International Journal of Environmental Research and Public Health·Corey M BenedumMartha M Werler
Jun 20, 2014·British Journal of Haematology·Vinod DevaliaUNKNOWN British Committee for Standards in Haematology
Aug 1, 1986·Alcoholism, Clinical and Experimental Research·K E McMartinH M Redetzki
May 26, 2001·Annual Review of Nutrition·J R SuhP J Stover
Aug 28, 2003·Alimentary Pharmacology & Therapeutics·F StickelH K Seitz
Jul 10, 2007·The American Journal of Clinical Nutrition·Vishnudutt PurohitSamir Zakhari
Dec 1, 2001·Nutrition Research Reviews·I A BrouwerR P Steegers-Theunissen
Nov 9, 2012·Molecular Nutrition & Food Research·Valentina Medici, Charles H Halsted
Aug 15, 2000·Annual Review of Nutrition·C S Lieber
Nov 22, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Bhawana Sharma, Rajesh Dabur
Jan 5, 2021·Global Medical Genetics·Syed Aaquil Hasan Syed Javid HasanElene Abzianidze
Dec 26, 2001·The Journal of Laboratory and Clinical Medicine·S MaruyamaK Umeki
Jan 1, 1987·Pharmacology & Therapeutics·C H Halsted, C Heise
Apr 29, 1994·Biochemical Pharmacology·N HidiroglouJ Selhub
Apr 15, 1989·Biochemical Pharmacology·D D Koblin, B W Tomerson
Mar 1, 1984·Alcohol·C S Lieber
Jul 25, 2021·Cancers·Francisco D Rodriguez, Rafael Coveñas
Aug 2, 2005·Alcohol·Joel B Mason, Sang-Woon Choi

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