Increased Urinary Excretion of Podocyte Markers in Normoalbuminuric Patients with Diabetes

Nephron
Eirini LioudakiEmmanouil S Ganotakis

Abstract

Podocyte injury plays a crucial role in the pathogenesis and progression of diabetic nephropathy (DN). We investigated whether patients with diabetes mellitus (DM) without overt DN present podocyte markers in urine suggestive of early podocyte injury. We studied 71 patients with DM type 2 and normal urine albumin excretion (UAE) and 39 non-diabetic controls. The mRNA abundance of 3 podocyte-specific markers in urinary sediment (nephrin, podocin and synaptopodin) was measured with real-time quantitative PCR. All the subjects were categorized according to their urinary podocyte marker profile into 2 groups, those with only synaptopodin mRNA presence (synaptopodin only group) and those with nephrin and/or podocin mRNA presence in addition to synaptopodin in their urine (nephrin and/or podocin group). Synaptopodin mRNA was detected in the urine of all the diabetics and controls. The presence of nephrin and/or podocin mRNA in urine was more frequent among DM patients compared to controls (53.5 vs. 30.8%, respectively; p = 0.022). Binary logistic regression analysis revealed that the only significant predictor of the presence of nephrin and/or podocin mRNA in urine was the presence of DM (OR 2.59, 95% CI 1.14-5.91, p = 0.024, adjuste...Continue Reading

Citations

Jul 15, 2016·Journal of Diabetes Research·Cristina GluhovschiBogdan Timar
May 17, 2017·Pflügers Archiv : European journal of physiology·Janina Müller-Deile, Mario Schiffer
Sep 15, 2019·Journal of Medical Genetics·Ivan D DoykovKevin Mills
Jul 14, 2020·Oxidative Medicine and Cellular Longevity·Akinjide Moses AkinnugaAndile Khathi
Dec 29, 2018·Biochemia Medica·Akankwasa GilbertXiaosong Qin

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