Increased urinary leukotriene E4 concentration in patients with eosinophilic pneumonia

The European Respiratory Journal
E OnoKazuo Akiyama

Abstract

Although eosinophils produce cysteinyl leukotrienes (CysLTs) in large quantities, information on the relationship between CysLTs and eosinophilic pneumonia (EP) is lacking. Inflammatory mediator concentrations in urine were quantified to clarify the relationship between CysLT concentrations and EP severity. Leukotriene (LT)E(4), eosinophil-derived neurotoxin (EDN), 9alpha,11beta-prostaglandin F2 and LTB(4) glucuronide concentrations were quantified in the urine of: EP patients during acute exacerbation and clinical remission; asthmatic patients during acute exacerbation and under stable conditions; and healthy control subjects. The urinary LTE(4) and EDN concentrations of EP patients during acute exacerbation were significantly higher than those of asthmatic patients and healthy subjects, and decreased immediately during clinical remission. The urinary LTE(4) concentration was associated with the urinary EDN concentration of EP patients during acute exacerbation. The urinary LTE(4) concentration significantly correlated with the diffusing capacity of the lung for carbon monoxide in EP patients during acute exacerbation. The increased urinary concentrations of leukotriene and eosinophil-derived neurotoxin were associated with ac...Continue Reading

Citations

Oct 5, 2012·Clinical Microbiology Reviews·Praveen Akuthota, Peter F Weller
Jul 22, 2015·The Journal of Allergy and Clinical Immunology·Chihiro MitsuiMasami Taniguchi
Oct 30, 2012·Immunology and Allergy Clinics of North America·Vincent Cottin, Jean-François Cordier
Apr 13, 2010·Prostaglandins & Other Lipid Mediators·Joseph H Butterfield
Oct 24, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Masami TaniguchiKazuo Akiyama
Aug 16, 2016·Clinics in Chest Medicine·Vincent Cottin
Feb 1, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kazuyuki NakagomeMakoto Nagata
Apr 25, 2020·Biomolecules·Kazuyuki Nakagome, Makoto Nagata

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