PMID: 8591705Aug 1, 1995Paper

Increased urinary N-acetyl-beta-glucosaminidase (NAG) excretion in young insulin-dependent diabetic patients

Diabetes Research and Clinical Practice
R LoriniG V Melzi d'Eril

Abstract

We evaluated urinary N-acetyl-beta-glucosaminidase (NAG) excretion in overnight and in second morning urine in 50 young diabetic patients, aged 7.4-25 years with a disease duration from 2-19.6 years. In all patients we evaluated urinary NAG and creatinine excretion, in both overnight and second morning urine, glycosuria, fasting blood glucose and HbA1c levels, insulin requirement, blood pressure, and the presence of microangiopathic complications. Urinary NAG excretion was also evaluated in 69 age- and sex-matched controls. NAG was determined using 3-cresolsulfonphtaleinyl-beta-N-acetylglucosaminide as substrate (Boehringer Mannheim, Germany). In the diabetic patients NAG/Cre ratios were significantly higher than in controls both in overnight and second morning urine (P < 0.0005, respectively). We observed significantly higher NAG/Cre ratio levels in the second morning than in overnight urine, both in controls and in diabetics (P < 0.0005, respectively). Elevated (above 2 S.D. of the mean) NAG/Cre ratios were found in 17/50 patients (34%) in overnight urine and in 29/50 (58%) in second morning urine. No correlation was observed between NAG/Cre ratio levels and age, duration of disease, pubertal stage, body mass index, fasting b...Continue Reading

References

Aug 16, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Fushimi, S Tarui
Sep 1, 1979·Histochemistry·M Le HirU Schmidt
Aug 16, 1975·British Medical Journal·J M WellwoodN F Jones
Apr 1, 1991·The Journal of Diabetic Complications·E MoritaS Eto
Nov 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·J SkrhaP Stolba
Dec 1, 1986·European Journal of Pediatrics·R LoriniF Severi
Feb 1, 1969·Archives of Biochemistry and Biophysics·S MahadevanA L Tappel
Jun 1, 1973·Biochemical Medicine·W R Den Tandt, M A Giesberts
Aug 1, 1995·Gastroenterology·F S Gorelick, L M Matovcik
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.