Increased Usage of Antiseptics Is Associated with Reduced Susceptibility in Clinical Isolates of Staphylococcus aureus

MBio
Katherine HardyMark Webber

Abstract

Hospital-acquired infection is a major cause of morbidity and mortality, and regimes to prevent infection are crucial in infection control. These include the decolonization of vulnerable patients with methicillin-resistant Staphylococcus aureus (MRSA) carriage using antiseptics, including chlorhexidine and octenidine. Concern has been raised, however, regarding the possible development of biocide resistance. In this study, we assembled a panel of S. aureus isolates, including isolates collected before the development of chlorhexidine and octenidine and isolates, from a major hospital trust in the United Kingdom during a period when the decolonization regimes were altered. We observed significant increases in the MIC and minimum bactericidal concentration (MBC) of chlorhexidine in isolates from periods of high usage of chlorhexidine. Isolates with increased MICs and MBCs of octenidine rapidly emerged after octenidine was introduced in the trust. There was no apparent cross-resistance between the two biocidal agents. A combination of variable-number tandem repeat (VNTR) analysis, PCR for qac genes, and whole-genome sequencing was used to type isolates and examine possible mechanisms of resistance. There was no expansion of a sing...Continue Reading

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Citations

Sep 29, 2019·Applied and Environmental Microbiology·Bárbara DuarteCarla Novais
Feb 2, 2019·Archives of Disease in Childhood·Lucy Jane Bock
Aug 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ahmed BabikerMary K Hayden
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Oct 1, 2020·International Journal of Molecular Sciences·Paweł KwiatkowskiBarbara Dołęgowska
Apr 11, 2019·Frontiers in Microbiology·Fabian CieplikAli Al-Ahmad
Jan 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paweł KwiatkowskiBarbara Dołęgowska
Mar 20, 2020·MSphere·Nichaela Harbison-PriceGregory M Cook
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Nov 12, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Madhuvanthi DhamodaranPaul Clarke
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Jul 1, 2020·International Journal of Antimicrobial Agents·Ruben BarretoStan Monstrey
Jun 3, 2021·Antibiotics·Nicholas SkandalisBrian Luna
Nov 1, 2021·Journal of Industrial Microbiology & Biotechnology·Laura J FoxAndrew J McBain

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Methods Mentioned

BETA
PCR

Software Mentioned

ARIBA
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