PMID: 3773514Sep 1, 1986Paper

Increased uterine uptake and nuclear retention of [3H]oestradiol through the oestrous cycle and enhanced end-organ sensitivity to oestrogen stimulation in vitamin B6 deficient rats

Journal of Steroid Biochemistry
J F BowdenE K Symes

Abstract

Vitamin B6 deficient female rats showed a significantly earlier, greater and more prolonged uptake of a tracer dose of [3H]oestradiol into the uterus, with increased nuclear accumulation, compared with vitamin B6 supplemented animals. This was most marked at oestrus, with little difference at anoestrus. The responses to low doses of ethynyl-oestradiol were greater in ovariectomized deficient animals than in those receiving the supplemented diet, with an increased uterotrophic response and greater induction of peroxidase. In the deficient animals there was virtually complete suppression of LH secretion at doses of ethynyl-oestradiol that had no effect in controls. At high doses of ethynyl-oestradiol there was no difference between the two groups of animals. The results suggest that increased uterine uptake and accumulation of [3H]oestradiol in vitamin B6 deficiency is associated with enhanced end-organ responsiveness to sub-maximal oestrogen stimulation, and that pyridoxal phosphate may have a coenzyme role in oestrogen action.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C R Lyttle, E R DeSombre
Jan 1, 1979·Methods in Enzymology·E Adams
Jan 13, 1978·Biochemical and Biophysical Research Communications·H NishigoriD Toft
Jun 29, 1978·Biochemical and Biophysical Research Communications·J A Cidlowski, J W Thanassi
Sep 1, 1985·The Journal of Clinical Endocrinology and Metabolism·H OkadaJ Kimura
Dec 1, 1985·Journal of Nutritional Science and Vitaminology·M Ikeda, M Okada
Apr 30, 1981·Biochemical and Biophysical Research Communications·D M DiSorbo, G Litwack
May 1, 1984·Journal of Steroid Biochemistry·E K SymesW F Coulson
Dec 1, 1981·Journal of Steroid Biochemistry·J A Cidlowski, J W Thanassi

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Citations

Sep 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·I GradzkaR Lorenc
Jan 1, 1990·The British Journal of Nutrition·D A BenderP S Danielian
Nov 1, 1994·The Proceedings of the Nutrition Society·D A Bender
May 13, 2006·Endocrinology·Song-Guang Ren, Shlomo Melmed

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