Increased vascular endothelial growth factor in patients with cyanotic congenital heart diseases may not be normalized after a Fontan type operation

The Annals of Thoracic Surgery
Kenji SudaMasahiko Matsumoto

Abstract

To determine the change of serum concentration of vascular endothelial growth factor (VEGF) in patients with cyanotic congenital heart disease (C-CHD). Patients comprised four groups: group A, 19 patients without cyanosis; group B, 24 patients with C-CHD; group C, 17 patients who had C-CHD and underwent biventricular repair; and group D, 15 patients who had single ventricle and underwent a Fontan type operation. Blood samples were obtained from upper arm veins and serum VEGF was determined. We determined correlation between serum VEGF and arterial oxygen saturation and compared levels of serum VEGF among groups. In addition, age and hemodynamic variables derived from cardiac catheterization were analyzed in terms of correlation with serum VEGF. Serum VEGF significantly negatively correlated with arterial oxygen saturation (r = -0.62, p < 0.0001). Serum VEGF in B and D were significantly higher than those in A and C (median = 443 pg/mL in B and 302 pg/mL in D vs 180 pg/mL in A and 216 pg/mL in C, respectively). Serum VEGF was significantly negatively correlated with patient's age (p = 0.54, p < 0.04) in D, but significantly positively correlated with systemic venous pressure (p = 0.45, p < 0.01) in pooled data. Patients with C-C...Continue Reading

References

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Citations

Nov 18, 2011·Heart and Vessels·S Mojtaba GolzanStuart L Graham
May 7, 2005·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Arthur E Baue
May 18, 2010·Cardiology in the Young·Anja Pohl-SchickingerBrigitte Stiller
Mar 6, 2013·Cardiology in the Young·Julien I E Hoffman
Apr 22, 2010·Italian Journal of Pediatrics·Nagla T El-Melegy, Nagwa A Mohamed
Apr 15, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Tatsuki MizuochiToyojiro Matsuishi
Nov 28, 2015·The Journal of Thoracic and Cardiovascular Surgery·Nefthi SandeepYoh-Suke Mukouyama
Nov 9, 2019·World Journal for Pediatric & Congenital Heart Surgery·Sara C ArrigoniTjark Ebels
Dec 12, 2019·Frontiers in Physiology·Julian Alexander HärtelMarijke Grau

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