Increased vascular endothelial growth factor transcription in residual hepatocellular carcinoma after open versus laparoscopic hepatectomy in a small animal model.

Surgical Endoscopy
Kyle A PerryBrett C Sheppard

Abstract

Vascular endothelial growth factor (VEGF) is overexpressed in hepatocellular carcinoma (HCC), and findings have shown that its upregulation in these tumors has an impact on tumor growth. The authors hypothesized that compared with open liver resection, laparoscopic hepatectomy would result in a decreased local angiogenic response in residual tumor cells. Right- and left-lobe hepatomas were induced in Buffalo rats via laparoscopically guided subcapsular injection of Morris hepatoma cells. After 1 week, the animals were randomized to laparoscopic or open left lateral hepatectomy. In 14 days after resection, the rats were killed, the residual right lobe tumors were measured, and tissue was procured for RNA extraction. Transcript levels of VEGF messenger RNA (mRNA) were quantified with reverse transcriptase-polymerase chain reaction (RT-PCR), and VEGF serum levels were measured by enzyme-linked immunoassay (ELISA) both before resection and at the time of tissue harvest. None of the animals had development satellite liver lesions or distant metastases in the abdomen or thorax. The median residual tumor volume was 320 mm(3) in the open group compared with 180 mm(3) in the laparoscopic group (p = 0.164). The animals that underwent ope...Continue Reading

References

Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·G CarlssonL Hafström
Aug 1, 1994·Diseases of the Colon and Rectum·G D HarmonM J Warzynski
Jan 12, 1996·The Journal of Biological Chemistry·T CohenB Z Levi
Oct 22, 1998·The British Journal of Surgery·M L Da CostaD Bouchier-Hayes
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshijiH Fukui
Mar 11, 1999·The New England Journal of Medicine·H B El-Serag, A C Mason
Jun 11, 1999·Annals of Surgery·Y FongL H Blumgart
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R T PoonJ Wong
May 18, 2001·Diseases of the Colon and Rectum·S DelgadoJ Visa
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 20, 2002·Annals of Surgery·Jean-François GigotUNKNOWN Hepatobiliary and Pancreatic Section of the Royal Belgian Society of Surgery and the Belgian Group for Endoscopic Surgery
Oct 5, 2002·Surgical Endoscopy·B DescottesJ F Gigot
Jun 17, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Woo Sung MoonAndrzej S Tarnawski
Sep 18, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Miguel PeraLawrence J Burgart
Nov 19, 2003·Annals of Internal Medicine·Hashem B El-SeragKatherine A McGlynn
Mar 2, 2005·Journal of the American College of Surgeons·Joseph F BuellE Steve Woodle

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Citations

Nov 18, 2011·Pathology, Research and Practice·Alton B FarrisHyun S Kim
Aug 28, 2013·Diagnostic and Interventional Imaging·J CazejustY Menu
Jun 25, 2010·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M R Schön
Apr 13, 2011·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·B EdwinA M Kazaryan

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