Increased vascular permeability, angiogenesis and wound healing induced by the serum of natural latex of the rubber tree Hevea brasiliensis

Phytotherapy Research : PTR
Ricardo José MendonçaJoaquim Coutinho-Netto

Abstract

Increases in vascular permeability and angiogenesis are crucial events to wound repair, tumoral growth and revascularization of tissues submitted to ischemia. An increased vascular permeability allows a variety of cytokines and growth factors to reach the damaged tissue. Nevertheless, the angiogenesis supply tissues with a wide variety of nutrients and is also important to metabolites clearance. It has been suggested that the natural latex from Hevea brasiliensis showed wound healing properties and angiogenic activity. Thus, the purpose of this work was to characterize its angiogenic activity and its effects on vascular permeability and wound healing. The serum fraction of the latex was separated from the rubber with reduction of the pH. The activity of the dialyzed serum fraction on the vascular permeability injected in subcutaneous tissue was assayed according Mile's method. The angiogenic activity was determined using a chick embryo chorioallantoic membrane assay and its effects on the wound-healing process was determined by the rabbit ear dermal ulcer model. The serum fraction showed evident angiogenic effect and it was effective in enhancing vascular permeability. In dermal ulcers, this material significantly accelerated w...Continue Reading

References

Dec 1, 1991·Pharmacology & Therapeutics·F Arnold, D C West
Apr 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·K UdakaH Z Movat
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Jun 26, 2001·International Journal of Dermatology·M A FradeN T Foss
May 16, 2003·Vascular Pharmacology·D O Bates, S J Harper
Jul 5, 2003·Physiological Reviews·Sabine Werner, Richard Grose
Jan 4, 2007·The American Journal of Pathology·Sabine A EmingAxel Roers
Nov 6, 2007·Progress in Histochemistry and Cytochemistry·Sabine A EmingManuel Koch

❮ Previous
Next ❯

Citations

Oct 2, 2009·Clinical Implant Dentistry and Related Research·Maya Fernanda Manfrin ArnezLuiz Antonio Salata
Jun 26, 2013·International Journal of Molecular Sciences·Celina M MiyazakiOsvaldo N Oliveira Jr
May 5, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Andre L A DomingosAntonio C P Martins
Jan 10, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Natan Roberto de BarrosAna Maria Queiros Norberto
Dec 19, 2019·Veterinary World·Abeer Ahmed Majeed, Dhyaa Ab Abood
Apr 21, 2016·Revista do Colégio Brasileiro de Cirurgiões·Maria Vitória Carmo PenhavelJoão Batista de Sousa
May 9, 2019·Applied Microbiology and Biotechnology·Bruna Cambraia GarmsRondinelli Donizetti Herculano
Jun 17, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Suelen PainiGerson Francisco Assis
Jun 29, 2018·Journal of Diabetes Research·Alberto López-DelisAdson Ferreira da Rocha
Feb 22, 2018·Future Microbiology·Mônica Yonashiro MarcelinoAna Marisa Fusco-Almeida
Feb 14, 2019·The American Journal of Sports Medicine·Diego Pulzatto CuryIi-Sei Watanabe
Jun 1, 2020·Anais Brasileiros De Dermatologia·Marcel Nani LeiteMarco Andrey Cipriani Frade
Oct 4, 2020·International Journal of Biological Macromolecules·Vaddarahally N ManjuprasannaBannikuppe S Vishwanath
Nov 7, 2020·Future Microbiology·Thainá V da SilvaRondinelli D Herculano
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Nayrim Brizuela GuerraRondinelli Donizetti Herculano
Mar 27, 2019·International Journal of Biological Macromolecules·Tamires KruppPaula Cristina de Souza Souto
Aug 18, 2021·Journal of Thrombosis and Haemostasis : JTH·Surasak WichaiyoNoppawan Phumala Morales
Aug 2, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Eder José GuidelliOswaldo Baffa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral Science
Cláudia A C A BalabanianLuiz G Brentegani
Anais Brasileiros De Dermatologia
Marco Andrey Cipriani FradeNorma Tiraboschi Foss
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Hui WangLian Duan
© 2022 Meta ULC. All rights reserved