Abstract
Increased vascular resistance during systemic nitric oxide synthase (NOS) inhibition is dependent on adrenergic vasoconstriction. This study tested the hypothesis that increased vascular sensitivity to adrenergic agonists contributes to this vasoconstriction. Superior mesenteric arteries and thoracic aortae from male Sprague-Dawley rats drinking water containing N omega-nitro-L-arginine (L-NNA; 14 days, 60 mg.kg-1.day-1) and control rats were-cut into helical strips, and endothelium was removed for contractile experiments. L-NNA arteries were more sensitive to UK-14304 (alpha 2-adrenergic agonist) and norepinephrine (NE), whereas responses to phenylephrine (PE) were not different concentration causing 50% maximal response (EC50), L-NNA vs. control: UK-14304, 0.071 vs. 0.71 mumol/l; NE, 1.15 vs. 9.95 nmol/l]. Yohimbine, an alpha 2-selective antagonist, caused a concentration-dependent inhibition of contraction to NE only in L-NNA arteries (EC50 = 6.3 vs. 1.6 nmol/l at 1 nmol/l yohimbine), whereas prazosin shifted NE curves similarly in arteries from both groups. Yohimbine (10 nmol/l) inhibited contractions to UK-14304 (EC50 = 59 mumol/l vs. 17 mumol/l) but not contractions to PE, whereas prazosin inhibited both. These data indic...Continue Reading
References
Jun 1, 1992·Pharmacology & Toxicology·M C MichelO E Brodde
Apr 1, 1990·Journal of Cardiovascular Pharmacology·A G ShiE E Daniel
Jan 1, 1991·Advances in Experimental Medicine and Biology·N J Rusch, W J Stekiel
Feb 1, 1990·British Journal of Pharmacology·C J DalyV G Wilson
Mar 1, 1989·Journal of Cardiovascular Pharmacology·M C MichelO E Brodde
May 1, 1985·Pharmacology, Biochemistry, and Behavior·R R Ruffolo
Sep 10, 1985·European Journal of Pharmacology·M Dashwood, M Jacobs
Apr 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·R A MaciaR M DeMarinis
Jan 16, 1981·European Journal of Pharmacology·J C Van MeelP A Van Zwieten
Sep 1, 1994·Blood Pressure·S W WattsR C Webb
Oct 1, 1995·Circulation Research·K Sumii, N Sperelakis
Nov 1, 1995·Hypertension·C F KüngT F Lüscher
Apr 1, 1995·American Journal of Hypertension·M HuangR L Hester
Jan 1, 1993·Hypertension·N TodaT Okamura
Jan 1, 1993·British Journal of Pharmacology·H Najafipour, W R Ferrell
Jun 24, 1993·European Journal of Pharmacology·H TsaiS P Duckles
Mar 1, 1993·Hypertension·J DananbergR J Grekin
Jul 1, 1995·Cellular Signalling·J Mironneau, N Macrez-Leprêtre
Aug 1, 1995·British Journal of Pharmacology·M O'RourkeJ R Docherty
Aug 1, 1995·British Journal of Pharmacology·N A Parkinson, A D Hughes
Dec 1, 1995·Journal of Cardiovascular Pharmacology·H ShimamotoE E Daniel
Aug 9, 1996·Science·R E LinkB K Kobilka
Aug 1, 1996·Pflügers Archiv : European journal of physiology·J ZanzingerH Seller
Sep 1, 1996·Hypertension·D HenrionJ B Michel
Feb 1, 1997·Circulation Research·Y IshibashiR J Bache
Jan 1, 1997·Pflügers Archiv : European journal of physiology·K Tewari, J M Simard
Citations
Feb 9, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y ToganeS Katayama
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Ian N BratzNancy L Kanagy
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Rebecca W Carter, Nancy L Kanagy
Jul 12, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Brett M MitchellR Clinton Webb
Aug 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ian N Bratz, Nancy L Kanagy
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Rebecca W CarterNancy L Kanagy
May 20, 2005·Brain : a Journal of Neurology·Olaf WindmüllerJens P Dreier
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H Mukundan, N L Kanagy
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Rebecca W Carter, Nancy L Kanagy
Mar 29, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ian N BratzNancy L Kanagy
May 10, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ian N BratzGregory M Dick
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C F Plato