Increased ventricular cerebrospinal fluid lactate in depressed adolescents

European Psychiatry : the Journal of the Association of European Psychiatrists
K A L BradleyVilma Gabbay

Abstract

Mitochondrial dysfunction has been increasingly examined as a potential pathogenic event in psychiatric disorders, although its role early in the course of major depressive disorder (MDD) is unclear. Therefore, the purpose of this study was to investigate mitochondrial dysfunction in medication-free adolescents with MDD through in vivo measurements of neurometabolites using high-spatial resolution multislice/multivoxel proton magnetic resonance spectroscopy. Twenty-three adolescents with MDD and 29 healthy controls, ages 12-20, were scanned at 3T and concentrations of ventricular cerebrospinal fluid lactate, as well as N-acetyl-aspartate (NAA), total creatine (tCr), and total choline (tCho) in the bilateral caudate, putamen, and thalamus were reported. Adolescents with MDD exhibited increased ventricular lactate compared to healthy controls [F(1,41)=6.98, P=0.01]. However, there were no group differences in the other neurometabolites. Dimensional analyses in the depressed group showed no relation between any of the neurometabolites and symptomatology, including anhedonia and fatigue. Increased ventricular lactate in depressed adolescents suggests mitochondrial dysfunction may be present early in the course of MDD; however it is...Continue Reading

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Citations

May 29, 2016·CNS Neuroscience & Therapeutics·Elísabet Alcocer-GómezMario D Cordero
Sep 12, 2017·Translational Psychiatry·V GabbayD C Shungu
Mar 21, 2017·Nordic Journal of Psychiatry·Trine EllegaardVibeke Bliksted
Aug 11, 2018·Medicine·Xiuli SongXiaohong Ma
Aug 28, 2019·Biomolecules·Brent M KiousPerry F Renshaw
Mar 7, 2019·Frontiers in Molecular Neuroscience·Benjamin SpurnyRupert Lanzenberger
Dec 9, 2020·Journal of Affective Disorders·Weibin HuangJing Zhang

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