PMID: 2117072Sep 1, 1990Paper

Increased virulence of a mouse-adapted variant of influenza A/FM/1/47 virus is controlled by mutations in genome segments 4, 5, 7, and 8

Journal of Virology
E G Brown

Abstract

To cause disease, influenza virus must possess several genetically determined abilities that mediate stages in pathogenesis. The virulent mouse-adapted variant A/FM/1/47-MA (FM-MA), derived from the avirulent A/FM/1/47 (FM) strain, had acquired mutations in genes that control virulence. The purpose of this study was to identify those genes that had mutated to result in increased virulence and to obtain viruses that differed in virulence because of differences in individual genome segments. The genes that had mutated to increase virulence were initially identified by genetic analysis of reassortants obtained by crossing FM-MA with the avirulent strain A/HK/1/68 (HK). FM-MA genome segments 4, 5, 7, and 8 were significantly associated with virulence, as determined by using the Wilcoxon ranked sum analysis. The role of FM-MA segments 4, 7, and 8 was confirmed by reintroduction of these genes into the parental strain, which also provided virus strains that differed in virulence because of mutations in individual genome segments. Segments 4, 7, and 8 were responsible for a 10(3.6)-fold increase in virulence that was proportioned 10(2.2)-, 10(0.7)-, and 10(0.8)-fold, respectively. The role of segment 5 could not be confirmed on transf...Continue Reading

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Citations

Jan 1, 1995·Archives of Virology·H ScheiblauerR Rott
Sep 28, 2005·The Journal of General Virology·Irina A RudnevaNikolai V Kaverin
Jul 28, 2010·Experimental Biology and Medicine·Bojian ZhengKwok-Yung Yuen
Jul 2, 2010·Journal of Virology·Natalia A IlyushinaRichard J Webby
Mar 26, 2010·Journal of Virology·Risa NakamuraYasunobu Yoshikai
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·C F BaslerJ K Taubenberger
Sep 5, 2008·Journal of Virology·Rong HaiPeter Palese
Mar 20, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory A BoivinSilvia M Vidal
Oct 12, 2012·Archives of Virology·Yanfeng YaoZe Chen
Jun 4, 2020·Viruses·Irina KiselevaLarisa Rudenko
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·E G BrownM Nesrallah
Oct 24, 2014·The Journal of Biological Chemistry·Lisa JollyGisli Jenkins
Aug 13, 2010·Journal of Virology·Kevin M CoombsEarl G Brown
Aug 8, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Moyar Qing GeDavid Michael Kemeny
Dec 24, 2011·PloS One·Lili XuChuan Qin
Mar 2, 2016·PLoS Pathogens·Ahmad Bakur MahmoudAndrew P Makrigiannis
Nov 2, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Behzad YeganehAndrew J Halayko
Jul 1, 2017·Archives of Virology·Jeong-Hyun NamJeong-Ki Kim
Jun 29, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·E G Brown

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