Increased visceral adipose tissue as a potential risk factor in patients with embolic stroke of undetermined source (ESUS)

PloS One
Antti T MuuronenPirjo Mustonen

Abstract

The etiology of an ischemic stroke remains undetermined in 20-35% of cases and many patients do not have any of the conventional risk factors. Increased visceral adipose tissue (VAT) is a suggested new risk factor for both carotid artery atherosclerosis (CAA) and atrial fibrillation (AF), but its role in the remaining stroke population is unknown. We assessed the amount of VAT in patients with embolic stroke of undetermined source (ESUS) after excluding major-risk cardioembolic sources, occlusive atherosclerosis, and lacunar stroke. Altogether 58 patients (mean age 57.7 ± 10.2 years, 44 men) with ischemic stroke of unknown etiology but without CAA, known AF or small vessel disease underwent computed tomography angiography and assessment of VAT. For comparison VAT values from three different reference populations were used. Conventional risk factors (smoking, hypertension, diabetes, increased total and LDL-cholesterol, decreased HDL-cholesterol) were also registered. Mean VAT area was significantly higher in stroke patients (205 ± 103 cm2 for men and 168 ± 99 cm2 for women) compared to all reference populations (P < 0.01). 50% of male and 57% of female patients had an increased VAT area. In male patients, VAT was significantly h...Continue Reading

References

Oct 22, 1987·The New England Journal of Medicine·R D Mosteller
Jul 1, 1972·Journal of Chronic Diseases·A KeysH L Taylor
May 13, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R E SchoenL H Kuller
Apr 6, 1999·Radiology·T YoshizumiY Matsuzawa
Oct 19, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·I MertensL Van Gaal
Oct 26, 2002·JAMA : the Journal of the American Medical Association·Giovanni DavìCarlo Patrono
Nov 28, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V KarttunenM Hillbom
Nov 25, 2003·Journal of Thrombosis and Haemostasis : JTH·M T GuagnanoG Davì
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Jul 28, 2004·The American Journal of Clinical Nutrition·Wei ShenStanley Heshka
Mar 23, 2005·Current Opinion in Pharmacology·Max NieuwdorpHarry Büller
Jul 27, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·U SalmenniemiM Laakso
Oct 22, 2005·Annals of Neurology·Hakan AyWalter J Koroshetz
Jan 1, 1994·Obesity Research·L A Quetelet
Sep 6, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P Maurovich-HorvatU Hoffmann
Oct 25, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W ShenS Heshka
Jan 23, 2008·Journal of Thrombosis and Haemostasis : JTH·F GuerciniM Paciaroni
Feb 20, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Romero-CorralF Lopez-Jimenez
Aug 30, 2008·The Journal of Clinical Endocrinology and Metabolism·Peder WiklundPeter Nordström
Feb 25, 2010·Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology·Dilek BerkerSerdar Güler
Aug 13, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Mauro PepiUNKNOWN European Association of Echocardiography
Aug 28, 2010·Journal of the American College of Cardiology·M Obadah Al ChekakieJoseph G Akar
Feb 24, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F TossA Nordström
Apr 9, 2011·Obesity·Nicole E JenskyMatthew A Allison
Apr 13, 2011·Journal of Thrombosis and Haemostasis : JTH·F A HanzuM Diaz-Ricart
Aug 2, 2011·Current Cardiology Reviews·Adrià Arboix, Josefina Alió
Aug 13, 2011·Stroke; a Journal of Cerebral Circulation·Marie BodenantUNKNOWN MORGAM Project
Dec 20, 2011·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Apr 4, 2012·Clinical Endocrinology·Alain GautierPierre-Henri Ducluzeau
Apr 20, 2012·The British Journal of Radiology·B J KlopfensteinJ Q Purnell

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Citations

Apr 11, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Walaa A KeshkAzza A Ghali
Jul 30, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Jahae KimKi-Hyun Cho
Jul 22, 2019·Journal of the Neurological Sciences·Ki-Woong NamSeung-Sik Hwang
Mar 8, 2017·Stroke; a Journal of Cerebral Circulation·Robert G HartStuart J Connolly

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Software Mentioned

R Foundation for Statistical Computing
SPSS
EMBODETECT
R

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