Increased volume of conducting airways in idiopathic pulmonary fibrosis is independent of disease severity: a volumetric capnography study

Journal of Breath Research
Laurent PlantierChristophe Delclaux

Abstract

Bronchiectasis, bronchiolectasis, and bronchiolisation of alveolar regions are salient features of idiopathic pulmonary fibrosis (IPF). We asked whether IPF was associated with physiological changes consistent with increases in the volume of conducting airways, and whether airway volume was related to the severity of lung fibrosis. Patients with IPF (N  =  57, vital capacity-VC: 73  ±  20%), patients with non-IPF interstitial lung disease (non-IPF ILD, N  =  24, VC  =  78  ±  18%) and controls without lung disease (N  =  51, VC  =  112  ±  21%) underwent volumetric capnography for the determination of conducting airway volume using Fletcher's equal area method, reported to predicted total lung capacity to control for the effect of lung size (VDaw/TLCp, mL/L). VDaw/TLCp was higher in patients with IPF (45.3  ±  12.8 ml L(-1)) in comparison with controls (34.2  ±  11.0 ml L(-1), p  <  0.0001) and patients with non-IPF ILD (39.5  ±  9.2 ml L(-1), p  =  0.0496). The same differences were observed when analysis was restricted to subjects with moderate IPF (VC  ⩾  80% predicted). Among IPF patients, VDaw/TLCp was correlated with neither the mMRC dyspnea scale, nor VC, nor carbon monoxide transfer factor, nor computed tomography fibro...Continue Reading

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Citations

Mar 25, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sylvia NyilasManuela Funke
Jan 26, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Laurent PlantierBruno Crestani
Oct 28, 2019·The European Respiratory Journal·Camila M CostaJaquelina Ota-Arakaki
Sep 29, 2020·Frontiers in Bioengineering and Biotechnology·Sandrine Le GuellecLaurent Plantier
Aug 5, 2021·Experimental Lung Research·Habtamu B DersehKen J Snibson

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