Increases in blood flow of the female rabbit urethra following low dose estrogens

The Journal of Urology
S BatraE Widmark

Abstract

The effects of low doses (0.05 to 20 micrograms./kg.) of estradiol-17 beta (E2) and estriol (E3) on blood perfusion in the genitourinary tissues were examined two and 24 hours after an intra-arterial injection into rabbits. Whereas 0.05 microgram./kg. E2 or E3 caused no detectable change, 0.5 microgram./kg. of either E2 or E3 markedly increased blood flow measured after two hours in urethra, vagina and uterus. No significant increase in the blood flow in the urinary bladder or the ureters was observed. With 20 micrograms./kg. E2 or E3 a much greater increase (10 to 25-fold) in the blood flow in the urethra, vagina and uterus was observed after two hours. At this time a small increase (about two-fold) could also be measured in urinary bladder and ureters. Twenty-four hours after this treatment (20 micrograms./kg. E2 or E3), the blood flow in the urinary organs was not significantly different from the pretreatment values but it was still significantly elevated in uterus and vagina. These data show that the blood flow in the female urethra is just as sensitive to low doses of estrogens as uterus and vagina. Both E2 and E3 seem to be equally effective in increasing blood perfusion in the urogenital tissues.

References

Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Oct 15, 1977·American Journal of Obstetrics and Gynecology·W H ClewellG Meschia
Sep 26, 1972·Biochemical and Biophysical Research Communications·J N AndersonE J Peck
Apr 1, 1984·Journal of Steroid Biochemistry·J H Clark, B M Markaverich
Feb 1, 1983·The Journal of Urology·S C Batra, C S Iosif
Feb 1, 1984·Journal of Steroid Biochemistry·M Haukkamaa
Apr 1, 1984·Journal of Steroid Biochemistry·B S Katzenellenbogen
Dec 1, 1981·American Journal of Obstetrics and Gynecology·C S IosifB Astedt

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Citations

Feb 1, 1996·Scandinavian Journal of Urology and Nephrology·K PerssonK E Andersson
Jan 1, 1996·International Urogynecology Journal and Pelvic Floor Dysfunction·G Hohlbrugger
Jan 1, 1996·International Urogynecology Journal and Pelvic Floor Dysfunction·M IshigookaT Nakada
Sep 1, 1994·The Journal of Urology·E F MooneyJ M Fitzpatrick
Oct 3, 2001·Physiological Reviews·S NilssonJ A Gustafsson
Sep 1, 1990·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G BussolatiM Massobrio
Nov 1, 1987·The Journal of Urology·S C Batra, C S Iosif
Jan 1, 1997·International Urogynecology Journal and Pelvic Floor Dysfunction·S ShimonovitzS L Stanton
Jan 12, 2017·The Journal of Obstetrics and Gynaecology Research·Ching-Hung Hsieh, Tsung-Hsien Su
Jun 1, 1997·Endocrinology and Metabolism Clinics of North America·T L Griebling, I E Nygaard
Aug 31, 2021·American Journal of Physiology. Renal Physiology·Chang-Joon LeeDavid W Smith

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