Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression.

Blood
U A LopatinStephen E Straus

Abstract

Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder in which genetic defects in proteins that mediate lymphocyte apoptosis, most often Fas, are associated with enlargement of lymph nodes and the spleen and a variety of autoimmune manifestations. Some patients with ALPS have relatives with these same apoptotic defects, however, who are clinically well. This study showed that the circulating levels of interleukin 10 (IL-10) were significantly higher (P <.001) in 21 patients with ALPS than in healthy controls. Moreover, the peripheral blood mononuclear cells (PBMCs) and lymphoid tissues of these patients with ALPS contained significantly higher levels of IL-10 messenger RNA (mRNA; P <.001 and P <.01, respectively). By fractionating PBMC populations, disproportionately high concentrations of IL-10 mRNA were found in the CD4(-)CD8(-) T-cell population, expansion of which is virtually pathognomonic for ALPS. Immunohistochemical staining showed intense IL-10 protein signals in lymph node regions known to contain CD4(-)CD8(-) T cells. Nonetheless, in vitro studies showed no influence of IL-10 on the survival of CD4(-)CD8(-) T cells. Overexpression of IL-10 in patients with inherited apoptotic defects is strongly ass...Continue Reading

References

Feb 4, 1976·European Journal of Pediatrics·K Kellerer, I Mutz
Aug 1, 1992·The Journal of Clinical Investigation·M C SnellerW Strober
Mar 1, 1991·Journal of Clinical Ultrasound : JCU·M S MalzbergS L Halpern
Jan 1, 1991·Annual Review of Immunology·P L Cohen, R A Eisenberg
May 15, 1982·International Journal of Cancer. Journal International Du Cancer·A TogawaM Namba
May 1, 1982·Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society·A TogawaM Namba
Jan 1, 1995·Arthritis and Rheumatism·J J CushP E Lipsky
Jan 1, 1994·The Journal of Clinical Investigation·Y Levy, J C Brouet
Sep 1, 1996·The Journal of Clinical Investigation·J WuJ D Mountz
Sep 12, 1998·Science·J M Adams, S Cory
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·S Cory
Nov 12, 1998·The American Journal of Pathology·M S LimE S Jaffe
Feb 2, 1999·The Journal of Clinical Investigation·A K VaishnawK B Elkon
Mar 26, 1999·American Journal of Human Genetics·C E JacksonJ M Puck
Apr 3, 1999·Annals of Internal Medicine·S E StrausW Strober

❮ Previous
Next ❯

Citations

Jan 15, 2008·Journal of Clinical Immunology·João Bosco Oliveira, Sudhir Gupta
Feb 20, 2013·Journal of Clinical Immunology·Ivan J FussWarren Strober
Jun 6, 2003·Current Opinion in Immunology·Frédéric Rieux-LaucatFrançoise Le Deist
Sep 11, 2002·Cytokine & Growth Factor Reviews·Amy M BeebeRene de Waal Malefyt
Aug 30, 2002·British Journal of Haematology·Bridget T HeelanA David B Webster
Mar 9, 2006·Hematology·V Koneti Rao, Stephen E Straus
Dec 8, 2004·The Journal of Experimental Medicine·Jian Qiao ZhangWendy F Davidson
Mar 27, 2003·The American Journal of Surgical Pathology·Anke van den BergSibrand Poppema
Jan 29, 2008·The American Journal of Surgical Pathology·Leonhard MüllauerAndreas Chott
Mar 23, 2006·Annual Review of Immunology·Nicolas BidèreMichael J Lenardo
Dec 25, 2010·The Journal of Clinical Investigation·Aude Magerus-ChatinetFrédéric Rieux-Laucat
Mar 31, 2012·ISRN Hematology·Paul V Licciardi, Tom C Karagiannis
Jan 10, 2012·Annual Review of Immunology·Mickie H Cheng, Mark S Anderson
Jan 11, 2005·Current Opinion in Allergy and Clinical Immunology·João B Oliveira, Thomas Fleisher
Oct 9, 2009·International Reviews of Immunology·Nima RezaeiChristoph Klein
Aug 4, 2012·The Journal of Allergy and Clinical Immunology·Aude Magerus-ChatinetFrédéric Rieux-Laucat
Sep 14, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A Rensing-EhlC Speckmann
Mar 17, 2010·The Journal of Allergy and Clinical Immunology·Iusta CaminhaJoão Bosco Oliveira
Feb 23, 2010·Autoimmunity Reviews·Joseph C Turbyville, V Koneti Rao
Apr 22, 2008·Immunology and Allergy Clinics of North America·Helen C Su, Michael J Lenardo
Mar 16, 2005·American Journal of Ophthalmology·Wee-Kiak LimRobert B Nussenblatt
Nov 1, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marla M VacekJennifer M Puck
Nov 18, 2005·The Journal of Pediatrics·Jack J H Bleesing
Mar 1, 2003·Paediatric Drugs·Jutte van der Werff ten Bosch
Jan 13, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Hiroyuki MinemuraMitsuru Munakata
Aug 12, 2014·Blood·Frédéric Rieux-Laucat

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