Increases in ghrelin and decreases in leptin without altering adiponectin during extreme weight loss in male competitive bodybuilders

Metabolism: Clinical and Experimental
Jarek MäestuToivo Jürimäe

Abstract

The aim of this study was to investigate responses of ghrelin, leptin, and adiponectin to a weight reduction period of 10 weeks in male subjects with high lean body mass and low body fat values. Fourteen male bodybuilders (7 competitors: 28.3 +/- 10.3 years, 175.3 +/- 5.4 cm, 82.2 +/- 9.3 kg; 7 controls: 22.4 +/- 3.0 years, 182.4 +/- 6.9 cm, 85.3 +/- 10.5 kg) participated in this study. The subjects were tested 3 times: 11 weeks (TEST1), 5 weeks (TEST2), and 3 days (TEST3) before the national championships. Testing procedure included dual-energy x-ray absorptiometry scan; calculation of daily energy intake and expenditure; and venous blood sampling for fasting ghrelin, leptin, and adiponectin. In the competitors' group, a significant (P < .05) 4.1-kg loss of body fat was observed that resulted in 6.5% +/- 1.5% of the body fat at the end of the study. Ghrelin increased significantly by 20.4% by TEST2. By TEST3, ghrelin was further increased by 6% (P > .05). The pattern of leptin was opposite, with a significant 27.7% decrease at TEST2 and no further decrease at TEST3 (P > .05). No significant change was observed in adiponectin concentration during the study. In the control group, no significant changes in biochemical parameters ...Continue Reading

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Citations

Jul 31, 2008·European Journal of Applied Physiology·Raul RämsonJarek Mäestu
Sep 17, 2011·European Journal of Applied Physiology·R RämsonJ Mäestu
Dec 19, 2008·Medicine and Science in Sports and Exercise·Jaak JürimäeSerge P von Duvillard
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May 19, 2009·Journal of Women's Health·Chung-Hua HsuHen-Hong Chang
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May 4, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J StubbsM Raats
Mar 23, 2010·Metabolism: Clinical and Experimental·Jaak JürimäeSerge P von Duvillard
May 13, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Chung-Hua HsuPesus Chou
Feb 24, 2017·BMC Complementary and Alternative Medicine·Hafeedza Abdul RahmanAzizah Abdul Hamid
Feb 16, 2013·International Journal of Sports Physiology and Performance·Lindy M RossowJeffrey R Stout
Oct 1, 2019·Endocrine Journal·Takahiro SatoMasayasu Kojima
Jan 19, 2019·Sports·Jackson James PeosPaul Fournier

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