Increases in peptide Y-Y levels following oat beta-glucan ingestion are dose-dependent in overweight adults

Nutrition Research
Eleanor J BeckXu-Feng Huang

Abstract

Peptide Y-Y (PYY) is an anorexigenic hormone implicated in appetite control, and beta-glucan is a fiber known to affect appetite. We hypothesized that plasma PYY levels would increase in overweight human adults consuming increasing doses of beta-glucan. The objective was to test whether the effect could be seen with beta-glucan delivered through extruded cereals containing a high beta-glucan oat bran with demonstrated high molecular weight and solubility. Fourteen subjects consumed a control meal and 3 cereals of varying beta-glucan concentration (between 2.2 and 5.5 g), and blood samples were collected over 4 hours. Analysis of raw PYY data showed a trend toward significant increases over 4 hours. An increasing dose of beta-glucan resulted in higher levels of plasma PYY, with significant differences between groups from 2 to 4 hours post test-meal. Data for the area under the curve analysis also approached significance, with post hoc analysis showing a difference (P = .039) between the control and the highest dose of beta-glucan (5.5 g). The PYY levels at 4 hours were significantly different between the control and high-dose meal test (P = .036). There was a significant dose response, with a positive correlation between the gra...Continue Reading

References

Jul 4, 1992·JAMA : the Journal of the American Medical Association·C M RipsinM Kestin
Mar 7, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A FlintA Astrup
Jun 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Amanda SainsburyHerbert Herzog
Jan 30, 2009·The Journal of Nutrition·Kristiina R JuvonenLeila J Karhunen
Mar 17, 2009·Nutrition Research·Holly J WillisJoanne L Slavin

❮ Previous
Next ❯

Citations

Dec 21, 2011·Journal of Medicinal Food·David SánchezAmaya Aleixandre
Sep 10, 2014·The Proceedings of the Nutrition Society·Elaine PattersonCatherine Stanton
Jul 28, 2012·Nutrition Reviews·Lieselotte CloetensGunilla Onning
Jan 3, 2016·Nutrition Reviews·Candida J RebelloFrank L Greenway
Jun 11, 2016·International Journal of Food Sciences and Nutrition·Damien P BelobrajdicAnthony R Bird
Dec 22, 2011·Journal of Nutrition and Metabolism·D El KhouryG H Anderson
Dec 22, 2016·European Journal of Clinical Nutrition·S M M ZarembaR E Steinert
Dec 14, 2017·Journal of Agricultural and Food Chemistry·Joon Hyuk SuhChi-Tang Ho
Jul 6, 2014·Journal of Agricultural and Food Chemistry·Candida J RebelloJohn W Finley
Nov 4, 2021·Critical Reviews in Food Science and Nutrition·Rebecca MathewsYiFang Chu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.