Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats.

Anesthesia and Analgesia
Dimitry ShnaydermanDouglas E Raines

Abstract

Previous studies demonstrated that MAC for isoflurane directly correlates with the concentration of Na(+) in cerebrospinal fluid surrounding the spinal cord, the primary site for mediation of the immobility produced by inhaled anesthetics. If this correlation resulted from increased irritability of the cord, then infusion of increased concentrations of potassium (K(+)) might be predicted to act similarly. However, an absence of effect of K(+) might be interpreted to indicate that K(+) channels do not mediate the immobility produced by inhaled anesthetics whereas Na(+) channels remain as potential mediators. Accordingly, in the present study, we examined the effect of altering intrathecal concentrations of K(+) on MAC. In rats prepared with chronic indwelling intrathecal catheters, we infused solutions deficient in K(+) and with an excess of K(+) into the lumbar space and measured MAC for isoflurane 24 h before, during, and 24 h after infusion. Rats similarly prepared were tested for the effect of altered osmolarity on MAC (accomplished by infusion of mannitol) and for the penetration of Na(+) into the cord. MAC of isoflurane never significantly increased with increasing concentrations of K(+) infused intrathecally. At infused c...Continue Reading

References

Jul 1, 1978·Anesthesia and Analgesia·Y Tanifuji, E I Eger
Sep 1, 1967·Anesthesiology·J H EiseleM Muallem
Dec 1, 1993·Anesthesiology·J F Antognini, K Schwartz
Jun 1, 1993·Anesthesiology·J F Antognini
May 13, 1999·Nature Neuroscience·A J PatelM Lazdunski
Jun 3, 2000·The EMBO Journal·F MaingretE Honoré
May 26, 2001·Anesthesiology·M LiuJ Liu
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy
Jun 4, 2004·The EMBO Journal·C HeurteauxM Lazdunski
Jun 21, 2007·Anesthesia and Analgesia·Robert J BrosnanJames M Sonner

❮ Previous
Next ❯

Citations

Jul 1, 1994·Journal of Pharmaceutical and Biomedical Analysis·A A WahbiA A Gazy
Aug 21, 2008·Anesthesia and Analgesia·Edmond I EgerJames M Sonner

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.