PMID: 9446839Mar 7, 1998Paper

Increases in the concentrations of available iron in response to dietary iron supplementation are associated with changes in crypt cell proliferation in rat large intestine

The Journal of Nutrition
E K LundI T Johnson

Abstract

High concentrations of iron in the diet have been shown to increase chemically induced colorectal tumors in rats. It is therefore important to understand the influence of dietary iron on the concentration of unabsorbed iron in the large intestine and its distribution between soluble and insoluble pools in the luminal compartment. We sought to investigate this issue and to establish whether iron modifies mucosal cell proliferation, which is thought to influence initiation and progression through the adenoma carcinoma sequence. In the first experiment, four groups of seven rats were fed diets at two concentrations of iron, 29 and 102 mg/kg, with or without the addition of 2.5 g phytic acid/kg. The concentrations of iron in the contents of the large bowel extractable with water ("free iron") or a buffered EDTA solution ("exchangeable iron") were determined. The concentration of freely soluble iron increased approximately 100% with iron supplementation in both the cecum and the colon, and there was an approximately five- to sixfold increase in exchangeable iron at both sites (P < 0. 05). In a second experiment with identical feeding conditions, there was a significantly greater number of cell divisions per crypt in the colon of the...Continue Reading

References

Jan 1, 1990·Free Radical Biology & Medicine·C F Babbs
Jan 1, 1989·Free Radical Research Communications·M H BlakeboroughR F Bilton
Jul 1, 1994·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J A MatthewI T Johnson
Mar 16, 1994·Journal of the National Cancer Institute·R L NelsonP Bowen
Jan 1, 1994·Immunology Today·T M Buttke, P A Sandstrom
Feb 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E PorrecaF Cuccurullo
Feb 1, 1994·International Journal of Cancer. Journal International Du Cancer·P KnektT Hakulinen
Aug 1, 1993·The Journal of Pediatrics·M Ben HarizC Ricour
Jan 1, 1993·Nutrition and Cancer·E Graf, J W Eaton

❮ Previous
Next ❯

Citations

Jun 9, 2001·Nutrition Reviews·R L Nelson
Oct 19, 2004·Nutrition and Cancer·Jillian N M IlsleyDaniel W Rosenberg
Jan 13, 2015·Critical Reviews in Food Science and Nutrition·Joseph H AshmoreTerryl J Hartman
Jul 18, 2020·Nutrition Reviews·Oliver PhippsHafid O Al-Hassi
Feb 27, 1999·International Journal of Cancer. Journal International Du Cancer·I KatoE Riboli
Feb 16, 1999·The American Journal of Clinical Nutrition·E K LundI T Johnson
Aug 31, 2004·The Journal of Nutrition·Ram UritskiRam Reifen
Jan 21, 2006·International Journal of Cancer. Journal International Du Cancer·Amanda J CrossRashmi Sinha
May 10, 2007·Canadian Journal of Physiology and Pharmacology·François BlachierDominique Bouglé
Jul 15, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yuonne KnöbelBeatrice Louise Pool-Zobel
Apr 16, 2010·The Journal of Nutrition·Mónica N OrozcoAna Luisa Mendizábal de Montenegro
Jan 1, 2014·Journal of Nutritional Science and Vitaminology·Alexandre Rodrigues LoboCélia Colli
Mar 10, 2011·The Proceedings of the Nutrition Society·Elizabeth K LundIan T Johnson
Jul 3, 2015·International Journal of Cancer. Journal International Du Cancer·Ana Fonseca-NunesPaula Jakszyn
May 27, 2015·Nutrition Reviews·Hari PadmanabhanTariq Iqbal
Jan 13, 2006·European Journal of Clinical Investigation·K L JohnstonP A Sharp
Nov 27, 2004·Experimental Biology and Medicine·Danny R MooreMark M Huycke
Jan 1, 2007·Toxicology Mechanisms and Methods·Pooja VirAkhtar Mahmood
Oct 12, 2018·Pharmaceuticals·Bahtiyar Yilmaz, Hai Li
May 14, 2020·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Tengjiao GuoHaohao Wu
Nov 19, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ana Fonseca-NunesAntonio Agudo
Aug 6, 2002·Mutation Research·Michael GleiBeatrice L Pool-Zobel
Jun 8, 2021·Microbiological Research·Behnoush KhasheiiAbdolmajid Mohammadzadeh
Feb 16, 2002·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·J M PérèsD Bouglé
Jan 18, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Y KnöbelB L Pool-Zobel
Dec 13, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y KnöbelB L Pool-Zobel
Nov 8, 2014·Journal of Agricultural and Food Chemistry·G O Latunde-DadaP A Sharp

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.