Increases in thyrotropin-releasing hormone messenger RNA expression induced by a model of human temporal lobe epilepsy: effect of partial and complete kindling

Neuroscience
S M Knoblach, M J Kubek

Abstract

Thyrotropin-releasing hormone and its receptor are differentially distributed throughout the limbic forebrain. In addition to its neuroendocrine function, several non-endocrine central nervous system effects of thyrotropin-releasing hormone and its analogs have been reported, including anticonvulsant effects in animals and humans. Kindling, as a model of temporal lobe epilepsy, produces elevations of endogenous thyrotropin-releasing hormone specifically in seizure-prone limbic regions. The present study used semi-quantitative in situ hybridization to characterize changes in thyrotropin-releasing hormone messenger RNA that occurred during the kindling process (partial kindling), as well as after fully kindled seizures. No significant change in thyrotropin-releasing hormone messenger RNA was detected 1 h postictally, whereas significant elevations were detected in the granule cell layer of the hippocampal dentate gyrus, diffuse nuclei of the amygdala and in layers II and III of piriform and entorhinal cortices from 3 to 48 h after a single generalized seizure in fully kindled rats. Peak messenger RNA expression occurred from 6 to 12 h postictally, with a decline at 24 h, followed by a precipitous return to undetectable levels by ...Continue Reading

References

Sep 1, 1978·Neurosurgery·R Racine
Feb 15, 1978·Biological cybernetics·I Lieblich, S Amari
Oct 1, 1976·The Journal of Comparative Neurology·O Steward, S A Scoville
Aug 1, 1991·Brain Research. Molecular Brain Research·M ClarkT Nakajima
Oct 1, 1991·Brain Research. Molecular Brain Research·H ShinodaJ P Schwartz
Apr 10, 1991·European Journal of Pharmacology·H UjiharaS Takaori
Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·S Yatsugi, M Yamamoto
Jan 1, 1989·Annals of the New York Academy of Sciences·M J KubekS H Larsen
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G C YehJ O McNamara
Jan 1, 1989·Annals of the New York Academy of Sciences·T HökfeltJ Freedman
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I MocchettiE Costa
Feb 10, 1989·Cell·M Beato
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·M DragunowK Jansen
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y GeinismanL deToledo-Morrell
Jun 1, 1986·Experimental Neurology·A SzafarczykI Assenmacher
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Jan 1, 1981·The Kurume Medical Journal·K Inanaga, Y Inoue

❮ Previous
Next ❯

Citations

Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael J KubekMichael C Veronesi
Jan 30, 2002·Pediatric Neurology·Michael J Kubek, Bhuwan P Garg
Dec 15, 2007·Psychoneuroendocrinology·Mariana Gutiérrez-MariscalPatricia Joseph-Bravo
Apr 8, 2014·Molecular Neurobiology·Elke ClynenJean-Michel Rigo
Nov 25, 1998·Thyroid : Official Journal of the American Thyroid Association·A Sattin
Oct 24, 2007·Journal of Molecular Neuroscience : MN·Patricia de GortariPatricia Joseph-Bravo
Oct 26, 1999·Endocrine Reviews·E A Nillni, K A Sevarino
Oct 11, 2005·Neurochemistry International·P de GortariP Joseph-Bravo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.