Increasing γ-Aminobutyric Acid Content in Vegetable Soybeans via High-Pressure Processing and Efficacy of Their Antidepressant-Like Activity in Mice

Foods
Sz-Jie WuYuan-Tay Shyu

Abstract

This study applied high-pressure processing (HPP) technology to enrich the gamma aminobutyric acid (GABA) content in vegetable soybeans and evaluated its antidepressant efficacy on mice, with depression induced by the unpredictable chronic mild stress (UCMS) model. The optimal conditions for HPP, storage time, and storage temperature, as well as antidepressant-like effects of vegetable soybeans, were evaluated and discussed. HPP could effectively and significantly increase GABA content in soybean, with optimum conditions at 200 MPa. The GABA content in the whole vegetable soybean was 436.05 mg/100 g. In mice animal tests, the tail suspension test (TST) showed that the immobility time of the GABA group was significantly shorter than that of the control group. The total travel distance in the open field test (OFT) showed that depressed mice fed with the GABA feed exhibited exploratory behavior. The GABA group showed a significantly higher degree of sucrose preference than the control group. Both results indicate that the GABA feed could effectively alleviate depressive symptomatology. Regarding biochemical parameters, the fecal and serum corticosterone (CORT) levels in the control group increased to 104.86 pg/mg after the onset o...Continue Reading

References

Oct 1, 1988·Analytical Biochemistry·S A Cohen, D J Strydom
Mar 1, 1994·Psychopharmacology·A H YoungG Fink
Oct 26, 1999·Trends in Plant Science·B J ShelpM D McLean
Jul 30, 2002·Progress in Brain Research·Victoria ArangoJ John Mann
Mar 9, 2004·Trends in Plant Science·Nicolas Bouché, Hillel Fromm
Jul 23, 2004·Physiological Reviews·Bernhard BettlerMartin Gassmann
Aug 25, 2004·Behavioural Brain Research·Stéphanie PothionCatherine Belzung
Oct 28, 2005·The New England Journal of Medicine·J John Mann
Jun 27, 2006·Biological Psychiatry·Alex Dranovsky, René Hen
Mar 31, 2007·International Journal of Medical Sciences·Manuel T Velasquez, Sam J Bhathena
Jun 21, 2008·Behavioural Brain Research·Ipek YalcinAlexandre Surget
Jan 2, 2010·Journal of Agricultural and Food Chemistry·Shigeaki UenoTomoyuki Fujii
Aug 3, 2010·Frontiers in Behavioral Neuroscience·Naoki MatsuoTsuyoshi Miyakawa
Apr 9, 2013·Bioscience, Biotechnology, and Biochemistry·Shigeaki UenoTomoyuki Fujii
Jul 31, 2013·Journal of the Science of Food and Agriculture·Jae Hwan KimHyung Joo Suh
Nov 5, 2013·European Journal of Pharmacology·Brijesh G TaksandeNandkishor R Kotagale
Feb 24, 2015·Frontiers in Psychiatry·Susana MonteiroJoão José Cerqueira
Sep 25, 2016·Plant Physiology·Ángela María Sánchez-LópezJavier Pozueta-Romero
Feb 8, 2020·International Journal of Molecular Sciences·Yanhua CuiXiaojun Qu
Jun 9, 2020·Journal of Applied Microbiology·G PerpetuiniR Tofalo
Jul 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Snehasis ChakrabortyH N Mishra

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS
XLSTAT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]
Radhika DhakalKwang-Hyun Baek
© 2021 Meta ULC. All rights reserved