Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats

Reproduction : the Official Journal of the Society for the Study of Fertility
Cheryl A FryeMadeline E Rhodes


The progesterone metabolite and neurosteroid, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), has actions in the midbrain ventral tegmental area (VTA) to modulate lordosis, but its effects on other reproductively relevant behaviors are not well understood. Effects on exploration, anxiety, and social behavior resulting from inhibition of 3alpha,5alpha-THP formation, as well as 3alpha,5alpha-THP enhancement, were investigated in the midbrain VTA. Naturally sexually receptive, female rats (n=8-10/group) received infusions aimed at the midbrain VTA of vehicle, PK11195 (an inhibitor of neurosteroidogenesis), and/or indomethacin (an inhibitor of 3alpha,5alpha-THP formation from prohormones), and were subsequently infused with vehicle or FGIN 1-27 (a neurosteroidogenesis enhancer). The rats were then assessed in a behavioral battery that examined exploration (open field), anxiety (elevated plus maze), social (social interaction), and sexual (paced mating) behavior. Inhibition of 3alpha,5alpha-THP formation decreased exploratory, anti-anxiety, social, and sexual behavior, as well as midbrain 3alpha,5alpha-THP levels. Infusions of FGIN 1-27 following 3alpha,5alpha-THP inhibition restored these behaviors and midbrain 3alpha,5alpha-T...Continue Reading


Dec 27, 2013·International Journal of Endocrinology·Jordyn M StuartHeather B Bradshaw
Nov 26, 2013·Pharmacology, Biochemistry, and Behavior·Fay A Guarraci, Jessica L Bolton
Jun 6, 2009·The Journal of Sexual Medicine·Monica L AndersenSergio Tufik
Jun 16, 2009·Psychoneuroendocrinology·Sheryl S SmithHui Shen
Oct 22, 2011·British Journal of Pharmacology·Ashish Dhir, Michael A Rogawski
Jun 24, 2011·Journal of Neuroendocrinology·Cheryl A Frye
Sep 20, 2011·Journal of Psychopharmacology·Oliver G BoschThomas C Wetter
Mar 3, 2015·Molecular Endocrinology·Vimal SelvarajLan N Tu
Jul 30, 2010·Stress : the International Journal on the Biology of Stress·Paula J Brunton, John A Russell


Dec 1, 1978·Hormones and Behavior·M K McClintock, N T Adler
May 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H PurdyS M Paul
Nov 1, 1990·Journal of Reproduction and Fertility·Cheryl A Frye, Mary S Erskine
May 1, 1990·The Journal of Speech and Hearing Disorders·A Craig
Mar 1, 1974·Journal of Comparative and Physiological Psychology·J F Marshall, P Teitelbaum
Mar 1, 1972·Journal of Comparative and Physiological Psychology·D F Hardy, J F DeBold
Jan 1, 1984·Annual Review of Psychology·H H Feder
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·A P CruzF G Graeff
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·R J Rodgers, N J Johnson
Dec 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·V K PatchevO F Almeida
Oct 16, 1999·Journal of Neuroendocrinology·Cheryl A Frye, L E Bayon
Oct 16, 2001·International Review of Neurobiology·R C Brown, V Papadopoulos
Oct 16, 2001·International Review of Neurobiology·S R Engel, K A Grant
Dec 18, 2001·Brain Research. Brain Research Reviews·S H MellonN A Compagnone
Dec 18, 2001·Brain Research. Brain Research Reviews·E Plassart-Schiess, E E Baulieu
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Deborah A FinnTamara J Phillips
Mar 24, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Cheryl A FryeMadeline E Rhodes
Jul 7, 2007·Stress : the International Journal on the Biology of Stress·Alicia A Walf, Cheryl A Frye
Aug 31, 2007·Physiology & Behavior·Shuwen LiangLouis N Irwin
Sep 4, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Georgina M RenardMarta M Suárez
Sep 14, 2007·Brain Research Reviews·Paul MicevychKevin Sinchak

Related Concepts

Behavior, Animal
Enhanced S-Cone Syndrome
Entire Midbrain
Sexual Behavior, Animal

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.