PMID: 2510042Sep 1, 1989Paper

Increasing amyloid peptide precursor production and its impact on Alzheimer's disease

Neurobiology of Aging
M P Vitek

Abstract

Amyloid peptide precursor (APP) gene expression increases in the brains of patients with Alzheimer's disease (AD). Regulation of expression at the transcriptional and posttranscriptional levels contributes significantly to these increases. Polypeptide hormones stimulate the promoter of the APP gene resulting in increased levels of heterogeneous nuclear RNAs (hnRNA). Through splicing, these hnRNAs are processed into 3 or more mature APP RNAs. The amounts of each of these similar but nonidentical APP RNAs may yield ratios of APP proteins which are required for neuronal survival, pathogenesis of neurons and/or produce phenocopies of learning and memory mutants of Drosophila.

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Citations

Jun 12, 2012·The Journal of Biological Chemistry·Loredana SpoerriRoberto Cappai
Jan 25, 2002·Annals of the New York Academy of Sciences·R Coker
Jun 1, 2012·Evolutionary Applications·Frédéric ThomasMichel Raymond

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