Abstract
Association between body mass index (BMI) and glycemic control, comorbidities/complications, and health-related quality of life (HRQoL) was assessed in Chinese patients with type 2 diabetes mellitus (T2DM) enrolled in the Diabetes Disease Specific Programme. Surveys of 200 physicians and 2052 patients with T2DM captured demographic, clinical, and HRQoL information. Adjusted and unadjusted analyses were conducted across 3 BMI groups; normal (18.5-<24.0, n=998), overweight (24.0-<28.0, n=822), and obese (≥28.0, n=212). There were no between group differences in the achievement of glycated hemoglobin (HbA1c) <7.0% (48mmol/mol); however, compared with the normal BMI group, more obese patients had an HbA1c >9.0% (75mmol/mol; 4.3% vs 10.2%, P=0.002). More obese patients compared with normal BMI patients had hypertension (48.6% vs 35.3%, P<0.001), dyslipidemia (35.4% vs 18.8%, P<0.001), or both hypertension and dyslipidemia (24.1% vs 13.9%, P<0.001). Patients in the obese group reported worse HRQoL and greater effects of diabetes on their daily living. Obesity in Chinese patients with T2DM results in poor glycemic control, more comorbidities, and worse HRQoL. Management of these patients should include efforts to reduce weight. Select...Continue Reading
References
Oct 6, 1978·JAMA : the Journal of the American Medical Association·R StamlerR H Roberts
Sep 1, 1991·Diabetes Care·R R Henry, B Gumbiner
Dec 1, 1990·Diabetes Care·J A Galloway
Dec 1, 1990·Diabetes Care·S Genuth
May 1, 1983·Circulation·H B HubertW P Castelli
Nov 1, 1994·Diabetes Care·R H StraubJ Schölmerich
Nov 21, 1997·Medical Care·P Dolan
Aug 28, 2001·Diabetes Care·T A Hillier, K L Pedula
Jan 14, 2003·Archives of Internal Medicine·Imad M El-KebbiLawrence S Phillips
Mar 31, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·W B ChanJ C N Chan
Jul 28, 2004·Diabetes Care·Samuel KleinUNKNOWN American Society for Clinical Nutrition
Jan 30, 2007·Journal of the American College of Cardiology·Apoor S GamiVictor M Montori
Apr 17, 2008·Journal of Diabetes and Its Complications·Nicole YurginMaureen J Lage
Oct 2, 2008·Current Medical Research and Opinion·P AndersonJ Piercy
Sep 1, 2009·Journal of Diabetes and Its Complications·Dong-Churl SuhMichelle Baron
Aug 7, 2010·Southern Medical Journal·Grant C Fowler, Deepa A Vasudevan
Nov 11, 2010·BMC Public Health·He XuSimin Liu
Dec 4, 2010·Obesity Surgery·Ninh T NguyenPing Wang
Jun 18, 2011·Diabetes Care·Maria ChiuJack V Tu
Jul 7, 2011·PloS One·Paolo BoffettaJohn D Potter
Feb 7, 2012·Atherosclerosis·Guenther SilbernagelWinfried März
Oct 11, 2012·PloS One·Wenying YangJonathan Brown
Mar 23, 2013·PloS One·Xuhong HouUNKNOWN China National Diabetes and Metabolic Disorders Study Group
May 15, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·William A BlumentalsEriko Ogura
Nov 13, 2013·BMC Public Health·Xuhong HouWeiping Jia
Dec 19, 2013·Mediators of Inflammation·Snježana KaštelanMirela Karabatić
Jan 1, 2014·The Review of Diabetic Studies : RDS·Szu-chi Chen, Chin-Hsiao Tseng
Jan 5, 2014·The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association·Xiangyang TianYing Shi