Increasing brain tumor rates: is there a link to aspartame?

Journal of Neuropathology and Experimental Neurology
J W OlneyL N Robins

Abstract

In the past two decades brain tumor rates have risen in several industrialized countries, including the United States. During this time, brain tumor data have been gathered by the National Cancer Institute from catchment areas representing 10% of the United States population. In the present study, we analyzed these data from 1975 to 1992 and found that the brain tumor increases in the United States occurred in two distinct phases, an early modest increase that may primarily reflect improved diagnostic technology, and a more recent sustained increase in the incidence and shift toward greater malignancy that must be explained by some other factor(s). Compared to other environmental factors putatively linked to brain tumors, the artificial sweetener aspartame is a promising candidate to explain the recent increase in incidence and degree of malignancy of brain tumors. Evidence potentially implicating aspartame includes an early animal study revealing an exceedingly high incidence of brain tumors in aspartame-fed rats compared to no brain tumors in concurrent controls, the recent finding that the aspartame molecule has mutagenic potential, and the close temporal association (aspartame was introduced into US food and beverage market...Continue Reading

Citations

May 13, 2010·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·R Gürtler
Aug 9, 2011·Neurotoxicity Research·Omar M E Abdel-SalamJihan Seid Hussein
Sep 12, 2013·International Journal of Pharmaceutics·Katarzyna RegulskaMiłosz Regulski
May 23, 1998·Journal of the American Dietetic Association·V B Duffy, G H Anderson
Aug 29, 1998·Clinical Biochemistry·G A KarikasG Kokotos
Jan 23, 2013·The Proceedings of the Nutrition Society·Danika M MartynMichael J Gibney
Jul 16, 1997·Journal of the National Cancer Institute·J G GurneyS Preston-Martin
Apr 18, 2001·Current Opinion in Oncology·J G Gurney, N Kadan-Lottick
Mar 28, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·L HardellA Hallquist
Jun 1, 2007·Occupational and Environmental Medicine·Dorothée ProvostIsabelle Baldi
Aug 7, 2010·Comparative and Functional Genomics·Entissar S Alsuhaibani
Dec 21, 2013·Environmental Toxicology and Pharmacology·Yukari HorioMasaaki Kurasaki
Jul 31, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marina MarinovichCarlo La Vecchia
Feb 11, 2014·Cytotechnology·Serkan Yılmaz, Aslı Uçar
Oct 14, 2004·Drug and Chemical Toxicology·Eyyüp RencüzoğullariSongül Budak Diler
Aug 16, 2002·Regulatory Toxicology and Pharmacology : RTP·Harriett H ButchkoFriedrich K Trefz
Jan 5, 2002·Regulatory Toxicology and Pharmacology : RTP·H H Butchko, W W Stargel
Aug 23, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jae-Yong KimKyung-Hyun Cho
Sep 26, 2013·Journal of Immunoassay & Immunochemistry·F Rahiman, E J Pool
Dec 21, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Eyad M T Ali, Hany M A Sonpol
May 11, 2011·Public Understanding of Science·Iina HellstenLoet Leydesdorff
Sep 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingang HouChulhee Choi
Nov 23, 2006·Annals of the New York Academy of Sciences·Fiorella BelpoggiFranco Minardi
Aug 8, 2015·Journal of Basic and Clinical Physiology and Pharmacology·Oluwatosin A Adaramoye, Olubukola O Akanni
Jul 25, 2019·Archives of public health = Archives belges de santé publique·Erik Paul Millstone, Elisabeth Dawson
Jun 10, 2019·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·J F Tahmassebi, A BaniHani
Jun 21, 2001·The Annals of Pharmacotherapy·J D SmithJ G Gums
Nov 5, 2002·The Journal of Clinical Pediatric Dentistry·Michael W Roberts, J Timothy Wright
Sep 21, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Unhee LimArthur Schatzkin
May 17, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Selda Gezginci-OktayogluSehnaz Bolkent
Oct 18, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GallusC La Vecchia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.