Increasing cAMP antagonizes hypertrophic response to angiotensin II without affecting Ras and MAP kinase activation in vascular smooth muscle cells

FEBS Letters
T TakahashiM Yokoyama

Abstract

Angiotensin II (Ang II), a potent hypertrophic factor for vascular smooth muscle cells (VSMC), induces activation of the ras proto-oncogene product (Ras) and mitogen-activated protein (MAP) kinases, and tyrosine phosphorylation of a focal adhesion-associated protein, paxillin. Forskolin, a direct activator of adenylate cyclase, and dibutyryl cAMP (Bt2 cAMP), a membrane permeable cAMP analogue, potently inhibited Ang II-stimulated protein synthesis. However, they did not inhibit Ang II-induced activation of Ras and MAP kinases. Although both forskolin and Bt2 cAMP potently reduced background tyrosine phosphorylation of paxillin, they allowed Ang II to induce the same reaction. These results indicate that increasing cAMP antagonizes the hypertrophic response to Ang II without affecting Ras and MAP kinase activation in VSMC and suggest that it does not interrupt signaling from the Ang II receptor to focal adhesions.

References

Oct 1, 1990·Molecular and Cellular Biology·A J NaftilanA S Kraft
Nov 1, 1990·The Journal of Clinical Investigation·H ItohV J Dzau
Feb 1, 1982·The Journal of Cell Biology·S GuntherM A Gimbrone
Sep 7, 1995·Annals of the New York Academy of Sciences·J D GravesE G Krebs
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L M GravesE G Krebs
Apr 14, 1995·Science·E A Clark, J S Brugge
Apr 26, 1996·The Journal of Biological Chemistry·B SchiefferK E Bernstein

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Citations

Jan 20, 2010·Journal of Receptor and Signal Transduction Research·Jerry G WebbAyad A Jaffa
May 2, 2017·Canadian Journal of Physiology and Pharmacology·Estelle R Simo-CheyouAshok K Srivastava
Feb 7, 1998·Hypertension·T Force, J V Bonventre
Feb 12, 2005·Journal of Cellular Physiology·Stéphane PelletierSylvain Meloche
Feb 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Laurent LoufraniDaniel Henrion
Jan 31, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marja LuodonpääHeikki Ruskoaho
Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J G WebbS M Lanier

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