Increasing diagnostic accuracy with a cell block preparation from thin-layer endometrial cytology: a feasibility study

Acta Cytologica
Aspasia KyroudiP Karakitsos

Abstract

To investigate (1) the feasibility of preparing cell blocks by inverted filter sedimentation (IFS-CB) from endometrial samplings processed by the ThinPrep (TP) technique (Cytyc Corp., Boxborough, Massachusetts, U.S.A.), and (2) the possibility of increasing the diagnostic accuracy of TP endometrial cytology by examining the tissue architecture as an adjunctive method of detecting endometrial lesions. Three hundred one endometrial samplings were obtained, using the Endogyn endometrial device (Biogyn S. n.c., Italy), from perimenopausal and postmenopausal women. The endometrial samplings were collected in a vial with liquid fixative for the TP processing. One TP slide was prepared from each case. If adequate material remained in the vial after the TP slide preparation, it was processed for IFS-CB preparation. IFS-CB preparation was processed in 263 cases (87%) with adequate material. Diagnoses on IFS-CB preparations obtained by endometrial sampling matched those of the hysterectomy specimens. The addition of IFS-CB histology to the cytologic diagnosis by TP increased the diagnostic accuracy of endometrial cytology to 96.3% and 100% for benign/atrophic endometrium and adenocarcinoma, respectively (p = 0.39 and 0.46). In hyperplasi...Continue Reading

Citations

Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A M BuccolieroG L Taddei
Jul 23, 2009·Journal of Visualized Experiments : JoVE·George M Varsegi, Vinod Shidham
Jun 9, 2016·Chinese Medical Journal·Hui ZhangQin-Ping Liao
Nov 17, 2007·Diagnostic Cytopathology·John A MaksemStanley J Robboy
Jun 21, 2007·Diagnostic Cytopathology·Anna M BuccolieroGian L Taddei
Nov 27, 2009·Diagnostic Cytopathology·Chiyuki KanekoMuneo Iwai
Aug 13, 2014·Cytopathology : Official Journal of the British Society for Clinical Cytology·D JainV K Iyer

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