Increasing efficacy and reducing side effects in treatment of chronic anal fissures: A study of topical diazepam therapy

Medicine
Minh Tuan H HangShahriar Sedghi

Abstract

This is a single institution nonexperimental study intended to analyze the therapeutic efficacy of topical diazepam in treating symptoms of chronic anal fissures.Anal fissures are a common cause of anal pain. Conventional treatments include nonsteroidal anti-inflammatory drugs, topical creams, such as nitroglycerin and nifedipine, and surgery. However, these treatments are usually suboptimally efficacious or have deterring side effects.Patients at an outpatient community center with a diagnosis of a chronic anal fissure were prescribed either topical 2% (n = 19) or 4% (n = 18) diazepam cream between January 2013 and February 2015. We retrospectively analyzed their responses to treatment.All 19 patients using 2% diazepam cream experienced a positive response in pain, whereas 47.4% experienced a complete response, with a numerical rating scale (NRS) score of 0 (0-10). Eighty-eight percent of patients using 4% dose had a positive response in pain, whereas 23.5% experienced a complete response. Ninety-four percent of patients using 2% dose had a positive response in anal bleeding, whereas 68.8% experienced a complete response with an anal bleeding score (ABS) of 2 (2-9). Ninety-four percent of patients using 4% dose had a positive ...Continue Reading

References

Jul 1, 1994·Diseases of the Colon and Rectum·W R SchoutenJ J Auwerda
Jun 1, 1996·The British Journal of Surgery·S J WatsonR K Phillips
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·W R SchoutenM O Boerma
Jul 29, 2004·Current Problems in Surgery·Richard P BillinghamM Margarita Murphy
Jul 28, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J T JenkinsR G Molloy
May 31, 2011·Journal of Pain and Symptom Management·Marianne Jensen HjermstadUNKNOWN European Palliative Care Research Collaborative (EPCRC)
Mar 2, 2012·Clinics in Colon and Rectal Surgery·Karen N Zaghiyan, Phillip Fleshner
Mar 16, 2013·World Journal of Gastrointestinal Surgery·Akira TsunodaNobuyasu Kano
Aug 27, 2013·Asian Journal of Surgery·Muhammad I AslamRodrigo Figueiredo
Oct 13, 2014·Journal of Visceral Surgery·T Higuero

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Citations

Jul 22, 2020·Journal of Clinical Gastroenterology·Satish S C Rao, Eula P Tetangco

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Methods Mentioned

BETA
sedation

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CAMbase
IndMed
CAM
SAS
QUEST

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