Abstract
This is a single institution nonexperimental study intended to analyze the therapeutic efficacy of topical diazepam in treating symptoms of chronic anal fissures.Anal fissures are a common cause of anal pain. Conventional treatments include nonsteroidal anti-inflammatory drugs, topical creams, such as nitroglycerin and nifedipine, and surgery. However, these treatments are usually suboptimally efficacious or have deterring side effects.Patients at an outpatient community center with a diagnosis of a chronic anal fissure were prescribed either topical 2% (n = 19) or 4% (n = 18) diazepam cream between January 2013 and February 2015. We retrospectively analyzed their responses to treatment.All 19 patients using 2% diazepam cream experienced a positive response in pain, whereas 47.4% experienced a complete response, with a numerical rating scale (NRS) score of 0 (0-10). Eighty-eight percent of patients using 4% dose had a positive response in pain, whereas 23.5% experienced a complete response. Ninety-four percent of patients using 2% dose had a positive response in anal bleeding, whereas 68.8% experienced a complete response with an anal bleeding score (ABS) of 2 (2-9). Ninety-four percent of patients using 4% dose had a positive ...Continue Reading
References
Jul 1, 1994·Diseases of the Colon and Rectum·W R SchoutenJ J Auwerda
Jun 1, 1996·The British Journal of Surgery·S J WatsonR K Phillips
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·W R SchoutenM O Boerma
May 22, 1998·Epilepsia·J C CloydG D Novack
Mar 4, 2000·Diseases of the Colon and Rectum·D F AltomareR Lovreglio
Jul 29, 2004·Current Problems in Surgery·Richard P BillinghamM Margarita Murphy
Mar 2, 2005·The British Journal of Surgery·K-S Ho, Y-H Ho
Jul 28, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J T JenkinsR G Molloy
Aug 5, 2010·Techniques in Coloproctology·E KaramanlisE Fahantidis
Sep 17, 2010·Pain·Gérald ChanquesSamir Jaber
May 31, 2011·Journal of Pain and Symptom Management·Marianne Jensen HjermstadUNKNOWN European Palliative Care Research Collaborative (EPCRC)
Jun 21, 2011·Annals of Surgery·Morsal SamimApollo Pronk
Mar 2, 2012·Clinics in Colon and Rectal Surgery·Karen N Zaghiyan, Phillip Fleshner
Jun 14, 2012·Radiation Oncology·Shinya TakemotoMikio Mimura
Mar 16, 2013·World Journal of Gastrointestinal Surgery·Akira TsunodaNobuyasu Kano
Jul 3, 2013·BMC Gastroenterology·Scott M BerryAnn Yellowlees
Aug 27, 2013·Asian Journal of Surgery·Muhammad I AslamRodrigo Figueiredo
Oct 13, 2014·Journal of Visceral Surgery·T Higuero
Jan 15, 2015·CNS Drugs·Heather Ravvin McKee, Bassel Abou-Khalil