PMID: 9533260Apr 9, 1998Paper

Increasing efficiency from censored survival data by using random effects to model longitudinal covariates

Statistical Methods in Medical Research
J W Hogan, N M Laird

Abstract

When estimating a survival time distribution, the loss of information due to right censoring results in a loss of efficiency in the estimator. In many circumstances, however, repeated measurements on a longitudinal process which is associated with survival time are made throughout the observation time, and these measurements may be used to recover information lost to censoring. For example, patients in an AIDS clinical trial may be measured at regular intervals on CD4 count and viral load. We describe a model for the joint distribution of a survival time and a repeated measures process. The joint distribution is specified by linking the survival time to subject-specific random effects characterizing the repeated measures, and is similar in form to the pattern mixture model for multivariate data with nonignorable nonresponse. We also describe an estimator of survival derived from this model. We apply the methods to a long-term AIDS clinical trial, and study properties of the survival estimator. Monte Carlo simulation is used to estimate gains in efficiency when the survival time is related to the location and scale of the random effects distribution. Under relatively light censoring (20%), the methods yield a modest gain in effi...Continue Reading

References

Dec 1, 1992·Statistics in Medicine·A HeytingJ G Essers
Oct 1, 1992·Statistics in Medicine·M D Schluchter
Sep 15, 1994·Statistics in Medicine·D M Finkelstein, D A Schoenfeld
Jan 15, 1997·Statistics in Medicine·J W Hogan, N M Laird
Jan 15, 1997·Statistics in Medicine·J W Hogan, N M Laird
Jan 1, 1996·Lifetime Data Analysis·N P Jewell, J D Kalbfleisch

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Citations

May 8, 2001·Statistical Methods in Medical Research·J M Albert, H Yun
May 8, 2001·Statistical Methods in Medical Research·N G Becker, I C Marschner
Jul 22, 2004·Anaesthesia and Intensive Care·J L MoranA D Bersten
Sep 3, 2016·Statistical Methods in Medical Research·Silvia BacciSilvia Pandolfi
Feb 2, 2018·The International Journal of Biostatistics·Graeme L HickeyRuwanthi Kolamunnage-Dona
May 1, 2009·Test·Joseph G Ibrahim, Geert Molenberghs
Jun 24, 2003·Statistics in Medicine·Peter Slasor, Nan Laird
Jul 12, 2002·Statistics in Medicine·Mark D SchluchterPamela B Davis
Mar 14, 2021·Statistics in Medicine·Danilo AlvaresCarmen Armero

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